巴氯芬对狗的毒性

Q4 Veterinary
Vanmathi Arulselvam, D. Kamalakannan, Agnishwaran Ramajothi, Abiramy Prabavathy Arumugam, Vijayalakshmi Padmanadan
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引用次数: 0

摘要

简介:巴氯芬是一种中枢作用的骨骼肌松弛剂,用于控制人类的痉挛和疼痛。在用药过量的情况下,通常会出现一些临床症状,如发声、呕吐、共济失调、定向障碍、流涎、昏迷、虚弱、平躺和癫痫发作。病例报告:病例1-一只体重5公斤的两个月大的雌性斯皮兹幼犬被带到兽医诊所的小动物医学单元。印度普杜切里拉吉夫甘地兽医教育与研究所(RIVER),患有呕吐、发声和过去一小时烦躁不安的病史。在记录了病史后,发现这只狗不小心吃了四片巴氯芬片(每片10毫克)。立即用液体、活性炭和加水的高岭土(口服)处理动物。12小时后,临床症状逐渐减轻,第二天明显好转,幼犬完全康复。病例2-一只体重20公斤的6个月大的雄性拉布拉多犬被带到印度Puducherry RIVER的VCC小动物医学部门,过去两个小时有发声、躁动和流涎的历史。在考虑了病史后,发现这只狗不小心摄入了8片10毫克的巴氯芬片。立即用液体(注射)硫酸阿托品和活性炭与水混合(口服)治疗动物。在不到12小时的时间内,临床症状逐渐减轻,第二天明显改善,狗完全康复。结论:及时诊断并妥善处理毒理,可消除临床症状,补液治疗有助于动物康复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Baclofen Toxicity in Dogs
Introduction: Baclofen is a centrally-acting skeletal muscle relaxant used to control spasticity and pain in humans. In an overdose situation, the onset of clinical signs, such as vocalization, vomiting, ataxia, disorientation, salivation, coma, weakness, recumbency, and seizures, is usually noticed. Case report: Case 1- A two-month-old female Spitz pup weighing 5 kg was brought to the Small Animal Medicine unit of Veterinary Clinical. Complex (VCC), Rajiv Gandhi Institute of Veterinary Education and Research (RIVER), Puducherry, India, with a history of vomiting, vocalization, and restlessness for the past hour. After recording the history, it was revealed that the dog had accidentally consumed four Baclofen tablets (10 mg each). The animal was immediately treated with fluids, activated charcoal, and Kaolin mixed with water (orally). The gradual reduction in clinical signs was noticed by the lower of 12 hours, and a dramatic improvement was noticed the day after, and the pup recovered completely. Case 2- A six-month-old male Labrador dog weighing 20 kg was brought to the Small Animal Medicine unit of VCC, RIVER, Puducherry, India, with a history of vocalization, restlessness, and salivation for the past two hours. After considering the history, it was revealed that the dog had accidentally ingested eight Baclofen tablets of 10 mg. The animal was immediately treated with fluids (Injection) Atropine sulfate and activated charcoal mixed with water (orally). The gradual reduction of clinical signs was noticed in less than 12 hours, dramatic improvement was noticed the next day, and the dog recovered completely. Conclusion: Timely diagnosis and proper management of the toxicity with drugs can eliminate the clinical signs, and fluid therapy can help the animal’s recovery.
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期刊介绍: Each month, Advances in Small Animal Medicine and Surgery features abstracts of material from recent publications and presentations, followed by comments from specialists in the field. Small animal veterinarians and veterinary technicians gain new insight into specific topics and increase their skills in judging how to apply new tests and treatments in practice situations.
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