Modern Idea of the Mechanisms of Development and Predictors of Ulcerative Colitis Severity

Objective of the Review: To analyse available contemporary references about possible pathological mechanisms of ulcerative colitis (UC). Key Points. There are data on high prognostic significance of genetic and demographic factors, characteristics of intestinal microbiota in UC development; and the absence of genetic differences in UC morbidity. Results of a number of studies demonstrate favourable impact for UC from some environmental factors, such as smoking, appendectomy and obesity. A significant component of UC and, thus, a useful marker of the disease activity/severity and a potentially attractive pharmacological target for UC management is neutrophils. Conclusion. Understanding the pathogenic mechanisms and assessment of risk factors allow expanding the comprehensive aid to patients with UC. Keywords: ulcerative colitis, inflamed intestine, microbiota, risk factors, neutrophils.