异丙肾上腺素和狗的胰腺。

L. Bennett, A. Pap, S. Naruse, D. F. Magee
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引用次数: 0

摘要

1. 意识清醒的狗每100分钟的基础胰腺分泌量被0.75微克kg-1h-1异丙肾上腺素显著降低。预期的自发峰值只有在停药后才会出现。2. 服用心得安后,100分钟胰腺分泌量低于对照组,但高于异丙肾上腺素组。峰间间隔增大,近地点水平(峰间)高于对照组。蛋白峰值分泌量不变,但体积减小。3.胍乙啶没有消除周期性,但延长了峰间间隔。蛋白峰和100 min总量低于对照,体积近日点高于对照。4. 因此,β -肾上腺素受体刺激可抑制胰腺分泌。肾上腺素能拮抗剂发挥类似的抑制作用,表明交感神经系统在控制胰腺分泌中的复杂作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isoprenaline and the pancreas in dogs.
1. In conscious dogs basal pancreatic secretion per 100 min was significantly reduced by 0.75 microgram kg-1h-1 of isoprenaline. The expected spontaneous peaking was seen only after stopping the drug. 2. Following propranolol, the 100-min pancreatic secretion was less than control but greater than secretion after isoprenaline. The interpeak interval was increased, and the perigee levels (interpeak) were higher than in the controls. Peak protein secretion was unaltered but volume was reduced. 3. Guanethidine did not abolish periodicity but it prolonged the interpeak interval. Protein peaks and 100-min totals were lower than control and volume perigees higher. 4. It is concluded that beta-adrenoreceptor stimulation inhibits pancreatic secretion. Adrenergic antagonists exert similar inhibitory effects indicating a complex role for the sympathetic nervous system in the control of pancreatic secretion.
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