A. H. Lodyagin, A. Sinenchenko, Bair Vasilyevich Batotsyrenov, G. I. Sinenchenko
{"title":"高氨血症对急性重症1,4-丁二醇中毒谵妄综合征病程的影响及纠正方法","authors":"A. H. Lodyagin, A. Sinenchenko, Bair Vasilyevich Batotsyrenov, G. I. Sinenchenko","doi":"10.47470/0869-7922-2022-30-4-223-230","DOIUrl":null,"url":null,"abstract":"Introduction. The article presents an assessment of the effect of hyperammonemia on the course of delirious syndrome in acute severe poisoning with 1,4-butanediol and methods of its correction. Purpose of the study. to analyze the effect of free ammonia on the severity of delirium in acute severe poisoning with 1,4-butanediol and to develop methods for correcting hyperammonemia. Material and methods. In the course of the work, a prospective examination was carried out of 59 male patients aged 20 to 45 years (the average age was 29.2 ± 4.47 years) of the intensive care unit and intensive care center of the center for the treatment of acute poisoning of the St. I.I. Dzhanelidze with acute severe poisoning with 1,4-butanediol, complicated by delirious syndrome. The results were statistically processed using the Statistica for Windows software (version 10). Results. During the study, patients with delirious syndrome were diagnosed with transient hyperammonemia of moderate severity according to the classification proposed by Lazebnik L.B. et al. (2019) with hepatocellular insufficiency syndrome. The factor of the increase in free ammonia in the blood was protein catabolism and tissue hypoxia. The use of a hepatoprotector based on a compound of arginine and glutamic acid “Glutargin” made it possible to correct metabolic disorders and significantly reduce the duration of exogenous psychosis and minimize post-delirious complications in the form of psychoorganic syndrome and severe postpsychotic asthenia. Limitations. When studying the effect of hyperammonemia on the course of the delirious syndrome in acute severe poisoning with 1,4-butanediol, a prospective examination of 59 male patients of the intensive care unit was carried out, whose intensive care included arginine glutamate (Glutargin), which made it possible to establish the cause of the prolonged course of delirium and improve the tactics of its treatment. Conclusion. Obtained in the present The study results demonstrate the high efficacy of the hepatoprotector “Glutargin” in relation to slowing the progression of the clinical course of post-intoxication delirium in acute severe poisoning with 1,4-butanediol.","PeriodicalId":23128,"journal":{"name":"Toxicological Review","volume":"101 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of hyperammoniemia on the course of delirious syndrome in acute severe poisoning with 1,4-butandiol and methods of its correction\",\"authors\":\"A. H. Lodyagin, A. Sinenchenko, Bair Vasilyevich Batotsyrenov, G. I. Sinenchenko\",\"doi\":\"10.47470/0869-7922-2022-30-4-223-230\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction. The article presents an assessment of the effect of hyperammonemia on the course of delirious syndrome in acute severe poisoning with 1,4-butanediol and methods of its correction. Purpose of the study. to analyze the effect of free ammonia on the severity of delirium in acute severe poisoning with 1,4-butanediol and to develop methods for correcting hyperammonemia. Material and methods. In the course of the work, a prospective examination was carried out of 59 male patients aged 20 to 45 years (the average age was 29.2 ± 4.47 years) of the intensive care unit and intensive care center of the center for the treatment of acute poisoning of the St. I.I. Dzhanelidze with acute severe poisoning with 1,4-butanediol, complicated by delirious syndrome. The results were statistically processed using the Statistica for Windows software (version 10). Results. During the study, patients with delirious syndrome were diagnosed with transient hyperammonemia of moderate severity according to the classification proposed by Lazebnik L.B. et al. (2019) with hepatocellular insufficiency syndrome. The factor of the increase in free ammonia in the blood was protein catabolism and tissue hypoxia. The use of a hepatoprotector based on a compound of arginine and glutamic acid “Glutargin” made it possible to correct metabolic disorders and significantly reduce the duration of exogenous psychosis and minimize post-delirious complications in the form of psychoorganic syndrome and severe postpsychotic asthenia. Limitations. When studying the effect of hyperammonemia on the course of the delirious syndrome in acute severe poisoning with 1,4-butanediol, a prospective examination of 59 male patients of the intensive care unit was carried out, whose intensive care included arginine glutamate (Glutargin), which made it possible to establish the cause of the prolonged course of delirium and improve the tactics of its treatment. Conclusion. Obtained in the present The study results demonstrate the high efficacy of the hepatoprotector “Glutargin” in relation to slowing the progression of the clinical course of post-intoxication delirium in acute severe poisoning with 1,4-butanediol.\",\"PeriodicalId\":23128,\"journal\":{\"name\":\"Toxicological Review\",\"volume\":\"101 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicological Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47470/0869-7922-2022-30-4-223-230\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicological Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47470/0869-7922-2022-30-4-223-230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
介绍。本文评价了高氨血症对急性重症1,4-丁二醇中毒谵妄综合征病程的影响及纠正方法。研究目的:分析游离氨对急性重症1,4-丁二醇中毒谵妄严重程度的影响,探讨纠正高氨血症的方法。材料和方法。在工作过程中,对St. I.I. Dzhanelidze急性中毒治疗中心重症监护室和重症监护中心的59例男性患者(年龄20 ~ 45岁,平均年龄29.2±4.47岁)进行了前瞻性检查,这些患者合并急性重症1,4-丁二醇中毒并伴有谵妄综合征。使用Statistica for Windows软件(版本10)对结果进行统计处理。结果。在本研究中,谵妄综合征患者根据Lazebnik L.B. et al.(2019)提出的肝细胞功能不全综合征的分类诊断为中度的一过性高氨血症。血液中游离氨增加的因素是蛋白质分解代谢和组织缺氧。使用一种基于精氨酸和谷氨酸化合物的护肝剂,可以纠正代谢紊乱,显著减少外源性精神病的持续时间,并最大限度地减少精神器官综合征和严重精神衰弱形式的谵妄后并发症。的局限性。在研究高氨血症对急性重症1,4-丁二醇中毒谵妄综合征病程的影响时,对重症监护室59例男性患者进行了前瞻性检查,重症监护包括精氨酸谷氨酸(Glutargin),从而可以确定谵妄病程延长的原因并改进其治疗策略。结论。本研究结果显示护肝剂“谷氨酸”对减缓急性重症1,4-丁二醇中毒后谵妄临床病程的进展有很高的疗效。
Effect of hyperammoniemia on the course of delirious syndrome in acute severe poisoning with 1,4-butandiol and methods of its correction
Introduction. The article presents an assessment of the effect of hyperammonemia on the course of delirious syndrome in acute severe poisoning with 1,4-butanediol and methods of its correction. Purpose of the study. to analyze the effect of free ammonia on the severity of delirium in acute severe poisoning with 1,4-butanediol and to develop methods for correcting hyperammonemia. Material and methods. In the course of the work, a prospective examination was carried out of 59 male patients aged 20 to 45 years (the average age was 29.2 ± 4.47 years) of the intensive care unit and intensive care center of the center for the treatment of acute poisoning of the St. I.I. Dzhanelidze with acute severe poisoning with 1,4-butanediol, complicated by delirious syndrome. The results were statistically processed using the Statistica for Windows software (version 10). Results. During the study, patients with delirious syndrome were diagnosed with transient hyperammonemia of moderate severity according to the classification proposed by Lazebnik L.B. et al. (2019) with hepatocellular insufficiency syndrome. The factor of the increase in free ammonia in the blood was protein catabolism and tissue hypoxia. The use of a hepatoprotector based on a compound of arginine and glutamic acid “Glutargin” made it possible to correct metabolic disorders and significantly reduce the duration of exogenous psychosis and minimize post-delirious complications in the form of psychoorganic syndrome and severe postpsychotic asthenia. Limitations. When studying the effect of hyperammonemia on the course of the delirious syndrome in acute severe poisoning with 1,4-butanediol, a prospective examination of 59 male patients of the intensive care unit was carried out, whose intensive care included arginine glutamate (Glutargin), which made it possible to establish the cause of the prolonged course of delirium and improve the tactics of its treatment. Conclusion. Obtained in the present The study results demonstrate the high efficacy of the hepatoprotector “Glutargin” in relation to slowing the progression of the clinical course of post-intoxication delirium in acute severe poisoning with 1,4-butanediol.