芬兰到瑞典移民对内皮功能和内膜-中膜厚度影响的基于人群的双胞胎研究

L. Jartti, T. Rönnemaa, J. Kaprio, M. Järvisalo, J. Toikka, J. Marniemi, N. Hammar, L. Alfredsson, M. Saraste, J. Hartiala, M. Koskenvuo, O. Raitakari
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引用次数: 67

摘要

芬兰男性冠心病(CHD)死亡率高于瑞典男性。为了评估移民到冠心病死亡率较低的国家对亚临床动脉粥样硬化的影响,我们测量了从芬兰移民到瑞典的双胞胎早期功能和结构动脉粥样硬化血管的变化。我们测量了74对42 - 69岁的男性双胞胎(20对同卵双胞胎,54对异卵双胞胎)的常规冠心病危险因素、肱动脉血流介导扩张(FMD)、颈动脉内膜-中膜厚度和颈动脉顺应性,其中双胞胎中的一个在20多年前永久移民到瑞典。除了舒张压和体脂率在瑞典较高外,冠心病的危险因素没有显著差异。在所有受试者中,瑞典的平均FMD无显著性升高(5.7±4.3% vs 4.9±4.2%,P =0.22),但在同卵双胞胎中,FMD的差异非常显著(7.2±4.4 vs 3.7±2.9%,P =0.003)。瑞典和芬兰在颈动脉内膜-中膜厚度和颈动脉顺应性方面没有显著差异。我们得出结论,在芬兰同卵双胞胎中,移居到冠心病患病率较低的国家的双胞胎内皮功能更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Population-Based Twin Study of the Effects of Migration From Finland to Sweden on Endothelial Function and Intima-Media Thickness
Finnish men have higher coronary heart disease (CHD) mortality than Swedish men do. To assess the impact of migration to a country with lower CHD mortality on subclinical atherosclerosis, we measured early functional and structural atherosclerotic vascular changes in twins discordant for migration from Finland to Sweden. Conventional CHD risk factors, flow-mediated dilatation (FMD) of the brachial artery, carotid intima-media thickness, and carotid artery compliance were measured in 74 male twin pairs (20 monozygous, 54 dizygous), aged 42 to 69 years, in which co-one twin had migrated more than 20 years ago permanently to Sweden. There were no significant differences in CHD risk factors except for diastolic blood pressure and body fat percentage, which were higher in Sweden. In all subjects, mean FMD was non-significantly higher in Sweden (5.7±4.3% vs 4.9±4.2%, P =0.22), but in monozygous twins the difference in FMD was highly significant (7.2±4.4 vs 3.7±2.9%, P =0.003). There was no significant difference in intima-media thickness or carotid artery compliance between Sweden and Finland. We conclude that in Finnish monozygous twins the endothelial function is better among the twins that have migrated to a country with lower CHD prevalence.
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