Allison O. Mattes, David Russell, Evgeny Tishchenko, Yanzhou Liu, Robert H. Cichewicz, Sarah J. Robinson
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Application of 19F quantitative NMR to pharmaceutical analysis
The presence of fluorine in an active pharmaceutical ingredient (API) can impart important pharmacological attributes with regards to metabolism, stability, and selectivity. As such, nearly one-third of newly approved small molecule drugs contain at least one fluorine atom. 19F is 100% naturally abundant lending to virtually unimpeded detection of fluorine-containing molecules, even in complex mixtures. Despite these promising characteristics, the thorough evaluation of a method for 19F qNMR (quantitative NMR) has been lacking. Herein we present experimental methodology and optimized parameters for uniform quantitative sampling of fluorine-containing drugs and we compare results obtained using both gravimetric and absolute concentration methods for data reduction.
期刊介绍：
Concepts in Magnetic Resonance Part A brings together clinicians, chemists, and physicists involved in the application of magnetic resonance techniques. The journal welcomes contributions predominantly from the fields of magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), but also encourages submissions relating to less common magnetic resonance imaging and analytical methods.
Contributors come from academic, governmental, and clinical communities, to disseminate the latest important experimental results from medical, non-medical, and analytical magnetic resonance methods, as well as related computational and theoretical advances.
Subject areas include (but are by no means limited to):
-Fundamental advances in the understanding of magnetic resonance
-Experimental results from magnetic resonance imaging (including MRI and its specialized applications)
-Experimental results from magnetic resonance spectroscopy (including NMR, EPR, and their specialized applications)
-Computational and theoretical support and prediction for experimental results
-Focused reviews providing commentary and discussion on recent results and developments in topical areas of investigation
-Reviews of magnetic resonance approaches with a tutorial or educational approach
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