脑功能缺失和边缘癫痫是相互排斥的吗?疑难临床概念的实验研究

IF 0.2 Q4 PEDIATRICS
F. Onat, E. Eşkazan
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引用次数: 0

摘要

癫痫的神经生理学、分子生物学、神经免疫学、神经遗传学、神经影像学和神经药理学等多个学科取得了令人印象深刻的进展,促进了基础科学家、临床医生和其他学科专业人员之间的相互交流,从而确定了临床问题,然后设计了基础科学范式来测试神秘的临床问题。根据临床观察,遗传性(特发性)广泛性典型缺失和内侧颞叶癫痫在同一患者中共存是非常罕见和有争议的,我们针对同一个体的罕见共存,设计了一种实验方法来测试这一临床概念的有效性,并研究其潜在机制。在这里,我们提出了在典型的缺失和颞叶癫痫所涉及的回路中相互交叉作用的证据。这篇文章描绘了一个现象学的画面,并理解了在典型的缺失中相互作用的理论理解,作为遗传性广泛性癫痫和边缘癫痫的代表,癫痫发作通常从内侧颞叶开始。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Are Absence and Limbic Seizures Mutually Exclusive?: An Experimental Approach to Enigmatic Clinical Concept
Abstract The impressive advances in the several disciplines including neurophysiology, molecular biology, neuroimmunology, neurogenetics, neuroimaging, and neuropharmacology of epilepsies have been stimulating a mutual interaction among basic scientists, clinicians, and professionals from other disciplines, leading to the identification of clinical questions and then the design of basic science paradigms to test enigmatic clinical issues. Based on a clinical observation that the coexistence of genetic (idiopathic) generalized typical absence and mesial temporal lobe epilepsy in the same patient is extremely rare and debatable, we addressed the rare coexistence in the same individual, designed an experimental approach to test the validity of this clinical concept and to study the underlying mechanisms involved. Here we presented evidence of a mutual cross-interaction in the circuits involved in typical absence and temporal lobe epilepsy. This article delineates a phenomenological picture and comprehends a theoretical understanding of a mutual cross-interaction in typical absence as a representative of genetic generalized epilepsies and limbic epilepsy in which seizures often start from the mesial temporal lobe.
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来源期刊
自引率
0.00%
发文量
21
期刊介绍: The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.
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