包括脂肪族离子液体在内的植物细胞培养中紫杉醇和相关紫杉醇类化合物的产量提高

IF 0.6 4区工程技术 Q4 CHEMISTRY, MULTIDISCIPLINARY

Solvent Extraction Research and Development, Japan Pub Date : 2018-01-01 DOI:10.15261/SERDJ.25.125

Shinjiro Yamamoto, Y. Sonoda, T. Kataoka, S. Hayashi, H. Miyasaka

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引用次数: 1

摘要

本文报道了疏水离子液体(ILs)对红豆杉(Taxus cuspidata)悬浮细胞培养中10-去乙酰baccatin III、baccatin III和cepharomannine相关紫杉醇及相关紫杉醇烷的原位提取效果。采用n-甲基-正丙基吡啶双(三氟甲烷磺酰基)亚胺(PP13-TFSI)和n-甲基-正丁基吡啶双(三氟甲烷磺酰基)亚胺(P14-TFSI)两种脂肪族il。结果表明，这两种il对紫杉醇及相关紫杉醇类化合物均无细胞毒性，并能提高紫杉醇类化合物的产率。特别是疏水性较强的P14-TFSI，其紫杉醇和总紫杉烷的产率比PP13-TFSI提高了2倍以上，可能是一种有效的萃取剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Enhanced Productivity of Paclitaxel and Related Taxanes in Plant Cell Culture Including Aliphatic Ionic Liquids

We report here on hydrophobic ionic liquids (ILs) which enhance the productivity of paclitaxel and the related taxanes of 10-deacetyl baccatin III, baccatin III and cepharomannine with in situ extraction from an aqueous medium in the suspension cell culture of Taxus cuspidata in the IL-medium two phase culture system. Two aliphatic ILs of N-methyl-n-propylpiperidinium bis(trifluoromethane-sulfonyl)imide (PP13-TFSI) and N-methyl-n-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14-TFSI) were used. It was found that the two ILs had no cytotoxicity and enhanced productivity of paclitaxel and the related taxanes in the cell culture. In particular, the more hydrophobic P14-TFSI, which enhanced the productivity of paclitaxel and the total taxanes by a factor of more than 2 compared to PP13-TFSI, could be an effective extractant.

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来源期刊

Solvent Extraction Research and Development, Japan 工程技术-工程：化工

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

1 months

期刊介绍： Solvent Extraction Research and Development, Japan (Solvent Extr. Res. Dev., Jpn.) is a periodical issued from Japan Association of Solvent Extraction (JASE) containing papers dealing with all aspects of solvent extraction and their related methods, underlying principles, and materials. Original articles, notes, technical reports, and critical reviews will be considered for publication. Original articles must be of reasonably broad scope and significance to the solvent extraction. Notes will originally describe novel work of a limited nature or especially significant work in progress. Authors can contribute some information of novel techniques, equipment or apparatus, reagents and diluents for solvent extraction as technical reports. Critical reviews will be received from the authors to whom the editorial committee asked to contribute.