HISTOPATHOLOGICAL SPECTRUM OF GALL BLADDER IN CHOLECYSTECTOMY SPECIMENS – A STUDY OF 320 CASES IN A GOVERNMENT HOSPITAL

Background: The gall bladder is one of the most commonly receivedspecimens for histopathological examination and presents with a wide varietyof lesions ranging from inflammation to malignancy. The present study aims todetermine the histopathological spectrum of gallbladder lesions incholecystectomy specimens.Materials and Methods: The present study included 320 gallbladder specimensobtained from cholecystectomy procedures conducted at tertiary teachinghospital in Jammu. Cholecystectomy specimens received in the laboratory werefixed in 10% formalin and submitted to detailed gross examination.Haematoxylin and eosin was used to stain gallbladder sections from fundus,body and neck. Results: The present study included 320 cholecystectomyspecimens comprising predominantly of females (85%) with M:F ratio of 1:5.7.Maximum number of patients were between 31 and 40 years (31.9%). Out of320 cases, the maximum number of cases were of chronic calculouscholecystitis (271 cases, 84.7%) followed by chronic cholecystitis withcholesterolosis (14 cases, 4.4%). There were 9 cases of chronic acalculouscholecystitis. Other non-neoplastic lesions received were acute cholecystitis (4cases -1.3%), chronic cholecystitis with metaplasia (3 cases – 0.9%),xanthogranulomatous cholecystitis (12 cases – 3.8%), eosinophilic andfollicular cholecystitis (2 cases each – 0.6%) and adenocarcinoma gallbladder (2 cases - 0.6%).Conclusion: The histopathological spectrum of gallbladder disease aftercholecystectomy is quite varied ranging from inflammation to malignancy.Therefore, histopathological examination of gall bladder specimens is veryimportant for diagnosis and better management of patient.Keywords: Cholecystectomy, cholecystitis, gallbladder, histopathology