A new Bi(III)-based coordination complex: Treatment and nursing application values on pediatric pneumonia

In the current work, through applying the mixed-ligand generation method, [Bi4Cl8(PDC)2 (2,2′-bpy)4]·2MeCN (1), a fresh bismuth (III)-organic compound synthesized with the solvothermal reactions between 2,2′-bipyridine (2,2′-bpy); 2,6-pyridinedicarboxylic acid (H2PDC); and bismuth chloride. The structural characterization results show that complex 1 features a binuclear discrete structure which is further extended into a 1D chain–like supramolecular network via π–π interactions. Furthermore, the compound’s treatment and nursing application values on pediatric pneumonia was explored and the novel compound’s corresponding mechanism was also investigated. First of all, in our research, the enzyme-linked immunosorbent assay (ELISA) detection kit was employed for the determination of the inflammatory cytokines content released into alveolar lavage fluid. Subsequently, the adenosine 5‘-monophosphate (AMP)–activated protein kinase (AMPK) signaling pathway activation in alveolar epithelial cells was explored exploiting the real-time reverse transcription–polymerase chain reaction (RT-PCR). Molecular docking demonstrated that although multiple pyridine rings are presented in the Bi complex, however, only the carboxylate groups have been observed to interact with the active residues.