自体间充质干细胞成功治疗跟腱修复术后肌肉萎缩1例

H. Mubark
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引用次数: 3

摘要

在剧烈的身体活动中,包括脚突然旋转或快速加速时,跟腱会突然受到外力作用而断裂。跟腱断裂的初始处理包括非手术方法,但如果这种方法失败,则应进行手术治疗。这篇文章提出了一个44岁的女性病人谁有左跟腱断裂在一个无篮篮球比赛。最初的治疗是保守的,随后是自发的再破裂,这需要重建手术和肌腱转移。随后,她出现小腿肌无力和移植的跟腱肌连接处萎缩。她的表现是不能进行单次脚跟抬高,娱乐活动受损,小腿肌肉萎缩和无力。足踝残疾指数(FADI)评分为74。她选择了自体脂肪来源的扩展间充质干细胞疗法(MSCs)联合富血小板血浆(PRP)的试验。治疗6个月后,患者的日常活动得到了改善,在重建手术后的几年里,患者第一次可以进行脚跟抬高和慢速跑步。她的FADI评分上升到91.3,治疗后6个月的MRI显示肌肉-跟腱连接处信号增加,表明可能愈合。该病例提示单个MSCs和PRP的成功治疗结果,表明当小腿肌肉萎缩和无力时,可在跟腱断裂手术后尝试再生治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Successful Treatment with Autologous Mesenchymal Stem Cells Therapy for Muscle Wasting Post-Surgical Repair of Achilles Tendon: A Case Report
Tendon rupture occurs when sudden forces apply upon the Achilles tendon during vigorous physical activities that involve abrupt pivoting on a foot or fast acceleration. The initial management of Achilles tendon rupture consists of a non-operative approach, but if this fails, operational treatment should take place. This article presents a forty-four-year-old female patient who had a left Achilles tendon rupture during a netball game. Initially was treated conservatively, followed by re-rupturing it spontaneously, which required reconstruction surgery with a tendon transfer. Subsequently, she developed calf muscle weakness and atrophy at the grafted musculoachilles junction. Her manifestations were the inability to perform a single heel raise, impaired recreational activities, and calf muscle wasting and weakness. The Foot & Ankle Disability Index (FADI) score was 74. She elected for a trial of autologous adipose-derived expanded mesenchymal stem cell therapy (MSCs) combined with platelet-rich plasma (PRP). Six months following the treatment, she had a good outcome evidenced by improvement of daily activities, performing heel-raise, and slow running for the first time after several years post reconstruction surgery. Her FADI score rose to 91.3, and six months post-treatment MRI revealed increased signal at the musculo-achilles junction representing a possible healing process. This case suggests successful therapy outcome with a single MSCs and PRP, indicating regenerative therapy could be tried post Achilles rupture surgery when there is calf muscle wasting and weakness.
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