通过酚醛间隔剂高效制备聚合物负载的对映纯手性氨基醇

Vincent Levacher , Christina Moberg
{"title":"通过酚醛间隔剂高效制备聚合物负载的对映纯手性氨基醇","authors":"Vincent Levacher ,&nbsp;Christina Moberg","doi":"10.1016/0923-1137(94)00083-H","DOIUrl":null,"url":null,"abstract":"<div><p>Derivatives of protected phenols with chiral aminoalcohol or aminoether-containing substituents in the 4-position of the aromatic ring were prepared and shown to react readily, after deprotection, with chloromethylated styrene-divinylbenzene polymers. The chirality in the substituents originated either from the use of a chiral monomeric aminoalcohol derivative or from the introduction of a chiral epoxide, which in turn was ring opened by a chiral amine. The chiral epoxides were obtained by either asymmetric synthesis or starting from a chiral glycidyl derivative.</p></div>","PeriodicalId":20864,"journal":{"name":"Reactive Polymers","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-1137(94)00083-H","citationCount":"7","resultStr":"{\"title\":\"Efficient preparation of polymer-supported enantiopure chiral aminoalcohols via phenolic spacers\",\"authors\":\"Vincent Levacher ,&nbsp;Christina Moberg\",\"doi\":\"10.1016/0923-1137(94)00083-H\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Derivatives of protected phenols with chiral aminoalcohol or aminoether-containing substituents in the 4-position of the aromatic ring were prepared and shown to react readily, after deprotection, with chloromethylated styrene-divinylbenzene polymers. The chirality in the substituents originated either from the use of a chiral monomeric aminoalcohol derivative or from the introduction of a chiral epoxide, which in turn was ring opened by a chiral amine. The chiral epoxides were obtained by either asymmetric synthesis or starting from a chiral glycidyl derivative.</p></div>\",\"PeriodicalId\":20864,\"journal\":{\"name\":\"Reactive Polymers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0923-1137(94)00083-H\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reactive Polymers\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/092311379400083H\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive Polymers","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/092311379400083H","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7

摘要

在芳香环的4位上制备了手性氨基醇或含氨基醚取代基的受保护酚衍生物,结果表明,脱保护后,与氯甲基化苯乙烯-二乙烯基苯聚合物容易发生反应。取代基的手性源于使用手性单体氨基醇衍生物或引入手性环氧化物,而手性环氧化物又被手性胺开环。通过不对称合成或手性缩水甘油酯衍生物制备手性环氧化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficient preparation of polymer-supported enantiopure chiral aminoalcohols via phenolic spacers

Derivatives of protected phenols with chiral aminoalcohol or aminoether-containing substituents in the 4-position of the aromatic ring were prepared and shown to react readily, after deprotection, with chloromethylated styrene-divinylbenzene polymers. The chirality in the substituents originated either from the use of a chiral monomeric aminoalcohol derivative or from the introduction of a chiral epoxide, which in turn was ring opened by a chiral amine. The chiral epoxides were obtained by either asymmetric synthesis or starting from a chiral glycidyl derivative.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信