Kaplan-Meier和Cox比例风险回归在生存分析中的应用:生命周期委员会统计标准和指南

IF 4.9 3区环境科学与生态学 Q2 ENGINEERING, ENVIRONMENTAL

International Journal of Life Cycle Assessment Pub Date : 2023-05-17 DOI:10.54724/lc.2023.e8

S. Lee

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引用次数: 7

摘要

在医学研究中，分析现象发生所需的时间有时是至关重要的。然而，各种因素可能影响生存期或观察期的长度，删除特定数据可能导致偏倚结果。本文讨论了生存分析中最常用的Kaplan-Meier分析和Cox比例风险回归模型。第一步，我们将讨论生存分析中需要的时间概念，例如队列研究，然后是生存分析中处理的基本统计函数。在巩固了概念之后，指出了Kaplan-Meier生存分析的理解方法和实际应用。之后，我们将讨论包含多个协变量的Cox比例风险回归模型的分析方法。结合Cox比例风险回归结果的解释方法，讨论了检验Cox比例风险回归假设的方法，如对数-对数图。最后，我们简要解释了时间相关回归分析的概念。我们的目的是通过本文，让读者了解生存分析，并学习如何进行生存分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Kaplan-Meier and Cox proportional hazards regression in survival analysis: statistical standard and guideline of Life Cycle Committee

In medical research, analyzing the time it takes for a phenomenon to occur is sometimes crucial. However, various factors can contribute to the length of survival or observation periods, and removing specific data can lead to bias results. In this paper, we discuss the Kaplan-Meier analysis and Cox proportional hazards regression model, which are the most frequently used methods in survival analysis. For the first step, we shall discuss the temporal concepts needed in survival analysis, such as cohort studies and then the basic statistical functions dealt with in survival analysis. After solidifying the concepts, methods of understanding and practical application of the Kaplan-Meier survival analysis is noted. After that, we will discuss the analysis methods for the Cox proportional hazards regression model, which includes multiple covariates. With the interpretation method of Cox proportional hazards regression result, we then discuss methods for checking the assumptions of the Cox proportional hazards regression, such as log minus log plots. Finally, we briefly explain the concept of time-dependent regression analysis. It is our aim that through this paper, readers can obtain an understanding on survival analysis and learn how to perform it.

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来源期刊

International Journal of Life Cycle Assessment 环境科学-工程：环境

CiteScore

10.60

自引率

10.40%

发文量

100

审稿时长

8-16 weeks

期刊介绍： The International Journal of Life Cycle Assessment (Int J Life Cycle Assess) is the first journal devoted entirely to Life Cycle Assessment and closely related methods. LCA has become a recognized instrument to assess the ecological burdens and impacts throughout the consecutive and interlinked stages of a product system, from raw material acquisition or generation from natural resources, through production and use to final disposal. The Int J Life Cycle Assess is a forum for scientists developing LCA and LCM (Life Cycle Management); LCA and LCM practitioners; managers concerned with environmental aspects of products; governmental environmental agencies responsible for product quality; scientific and industrial societies involved in LCA development, and ecological institutions and bodies.