Suplementación de vitamina D y perfil lipídico en mujeres con síndrome de ovarios poliquísticos y deficiencia de vitamina D

Objective

To establish the effects of vitamin D supplementation on the lipid profile in women with polycystic ovary syndrome and vitamin D deficiency.

Material and methods

A randomised double-blind study was conducted on women with polycystic ovary syndrome and vitamin D deficiency (concentrations less than 20 ng/mL), who were assigned to receive 5,000 IU daily of vitamin D or paraffin oil for 12 weeks. General characteristics, hormonal concentrations and lipid profile values before and after treatment were compared.

Results

For the final analysis, 169 women were selected, 84 women in group A (cases) and 85 women in group B (controls). No significant differences were found between the groups in the general characteristics, sex hormone concentrations, or vitamin D (P=ns). After supplementation, the patients in group A showed a decrease in the concentrations of total cholesterol, triglycerides and low-density lipoproteins (P<.05). No significant differences were observed in high-density lipoprotein concentrations (P=ns). Vitamin D concentrations increased significantly (P<.0001). No significant differences in lipid profile were observed in these parameters in patients in group B (P=ns).

Discussion

Vitamin D supplementation in women with polycystic ovary syndrome and vitamin D deficiency leads to a significant decrease in the concentrations of cholesterol, triglycerides and low-density lipoproteins, without affecting high-density lipoprotein concentrations.