为va纳索诺娃院士诞辰100周年干杯。传染病和风湿病:从过去到未来

B. Belov, E. Nasonov
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引用次数: 0

摘要

在风湿病学中,感染病理学的问题是相当尖锐的。这主要是由于各种感染因子参与免疫炎性风湿病(IIRD)的发展,其中微生物起触发作用,触发炎症的免疫病理机制。这类疾病的生动例子是急性风湿热和反应性关节炎。莱姆病的传染病因已得到证实。一项同样困难的任务是防治共病感染(CI),由于背景疾病和使用免疫抑制药物引起的免疫状态的破坏,这往往使许多IIRD的病程复杂化。在IIRD患者的CI结构中,呼吸道病变占主导地位,因此有必要在这些患者中使用流感和肺炎球菌疫苗,因为这些患者死于这些感染的风险相当高。COVID-19大流行已成为全人类面临的挑战,在其发展过程中,病毒感染与许多广泛存在的慢性非传染性疾病之间的关系揭示了许多新的基础和医学问题,其中IIRDs占据了重要地位。作为抗击当前COVID-19大流行的方法之一,人们对广泛使用疫苗接种寄予厚望。讨论了使用无克隆抗体进行COVID-19暴露前预防的可能性,包括在IIRD患者中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
To the 100th anniversary of the birth of academician V.A. Nasonova. Infections and rheumatic diseases: from the past to the future
In rheumatology, the problem of infectious pathology is quite acute. This is primarily due to the participation of various infectious agents in the development of immuno-inflammatory rheumatic diseases (IIRD), in which microorganisms play a trigger role, triggering the immunopathological mechanisms of inflammation. Vivid examples of such diseases are acute rheumatic fever and reactive arthritis. The infectious etiology of Lyme disease has been proven. An equally difficult task is the fight against comorbid infection (CI), which often complicates the course of many IIRD due to a violation of the immune status caused by both the background disease and the use of immunosuppressive drugs. The predominance of respiratory tract lesions in the structure of CI in patients with IIRD makes it necessary to use influenza and pneumococcal vaccines in them, since the risk of deaths from these infections among these patients is quite high. During the development of the COVID-19 pandemic, which has become a challenge to all mankind, a large number of new fundamental and medical problems have been revealed concerning the relationship between viral infection and many widespread chronic non-communicable diseases, among which IIRDs occupy an important position. As one of the methods of combating the current COVID-19 pandemic, great hopes are pinned on the widespread use of vaccination. The possibility of using mo noclonal antibodies for pre-exposure prophylaxis of COVID-19, including in patients with IIRD, is discussed.
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