Effects of Local Application of Platelet Rich Fibrin versus Hyaluronic Acid on Postoperative Sequelae After Surgical Removal of Impacted Lower Third Molar

Objectives: This study aims to evaluate the effectiveness of local application of platelet rich fibrin and hyaluronic acid on postoperative sequelae after surgical extraction of impacted mandibular third molars. Materials and Methods: The research included a total of 66 healthy patients, from both genders, aged between 19-29 years partially erupted mandibular third molar. All procedures had been done under local anesthesia. Patients randomly divided into three groups. First group platelet rich fibrin and in the second group (Gengigel ® Prof Syringes, Ricerfarma) which contain 0.8% hyaluronic acid were applied in the post extraction socket of impacted lower third molar. In the third control group nothing was placed in the extraction sockets. Postoperative pain, swelling, and trismus were evaluated on the 1st, 3rd, and 7th postoperative days. Results: Hyaluronic acid 0.8% (Gengigel) showed significant reduction in both pain and swelling for the 1st and 3rd postoperative days when compared to the control group. Platelet rich fibrin group revealed a significant lower pain at 1st postoperative day and less swelling at 3rd postoperative day in comparison to the control group. No differences were determined among all groups in maximum mouth opening (trismus). Conclusions: The result of this study showed that both hyaluronic acid and platelet rich fibrin reduced the postoperative pain and swelling. However, the outcome of hyaluronic acid was more satisfied than the platelet rich fibrin in comparison to that of control group after wisdom teeth surgery.