Stereotactic radiotherapy vs. surgery in the treatment of colorectal cancer liver oligometastases

Results There were no severe radiation-induced morbidity in the SBRT group, only 9,5% of patients developed grade 1 toxicity. In the surgery group complication rate was 18%, 1 lethal outcome was noted. The median follow-up was 24.6 months in the radiotherapy group and 22.8 months in the surgery group (p>0,05). 2 year LC rates was 62% in the SBRT group and 80% in the surgery group (p=0,019), and the 2-year OS was69.5% in the SBRT group and 84.7% in the surgery group (p = 0,03). The median mean dose was 54 Gy. Dose ≥51 Gy, was s a significant factor of improved local control. Conclusion SBRT is a safe and effective method of providing local control of colorectal cancer liver oligometastases. High-dose SBRT in hypofractionation regimen in selected patients with colorectal liver oligometastaseses comparable in terms of local control with surgery. Further studies are required to individualize the indications for this treatment method and optimize its methodology. Key words: Stereotactic radiation therapy, colorectal cancer, oligometastatic liver disease, hepatic resection