2,6-和2,7-二取代蒽醌的合成及生物活性研究。

The Chinese Pharmaceutical Journal Pub Date : 2002-08-01 DOI:10.7019/CPJ.200208.0245

Chin-sheng Wu, Wen-Chien Chiu, Jih P. Wang, S. Kuo

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引用次数: 0

摘要

合成了一系列2,6 -和2,7 -二取代蒽醌，并评价了它们对肥大细胞和中性粒细胞脱颗粒以及中性粒细胞超氧化物形成的抑制作用。其中，蒽醌- 2,7 -二羧酸(10c)是最有前途的药剂。化合物10c显著抑制PCA反应及组胺和ltd4诱导的大鼠皮肤反应。

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Synthesis and Biological Activity of 2,6- and 2,7-Disubstituted Anthraquinones.

A series of 2, 6- and 2, 7-disubstituted anthraquinones was synthesized and evaluated for inhibition of mast cell and neutrophil degranulation as well as neutrophil superoxide formation. Among them, anthraquinone-2, 7-diearboxylie acid (10c) was the most promising agent. Compound 10c significantly inhibited the PCA reaction and histamine- and LTD4-induced skin reactions in rats.

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The Chinese Pharmaceutical Journal

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