{"title":"酰基胰酶的水解","authors":"Andrew Williams, G. Salvadori","doi":"10.1039/J29710002401","DOIUrl":null,"url":null,"abstract":"The hydrolysis rate constant for acylchymotrypsins correlates with the rate constant for reaction of hydroxide ion with the ethyl esters (slope = 0·64, r= 0·867) over a wide range of structure variation in the acyl group. The low sensitivity to change of acyl group and to change in σ for benzoylchymotrypsins (ρ= 1·55, r= 0·952) is suggested to be due to electrophilic participation at the carbonyl oxygen of the acyl group. Tosylchymotrypsin is suggested as a model for the tetrahedral adduct of 4-methylbenzoylchymotrypsin with water and the electrophiles are identified as the NH groups of gly-193, asp-194, and ser-195 peptide bonds.","PeriodicalId":17268,"journal":{"name":"Journal of The Chemical Society B: Physical Organic","volume":"12 1","pages":"2401-2406"},"PeriodicalIF":0.0000,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Hydrolysis of acylchymotrypsins\",\"authors\":\"Andrew Williams, G. Salvadori\",\"doi\":\"10.1039/J29710002401\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The hydrolysis rate constant for acylchymotrypsins correlates with the rate constant for reaction of hydroxide ion with the ethyl esters (slope = 0·64, r= 0·867) over a wide range of structure variation in the acyl group. The low sensitivity to change of acyl group and to change in σ for benzoylchymotrypsins (ρ= 1·55, r= 0·952) is suggested to be due to electrophilic participation at the carbonyl oxygen of the acyl group. Tosylchymotrypsin is suggested as a model for the tetrahedral adduct of 4-methylbenzoylchymotrypsin with water and the electrophiles are identified as the NH groups of gly-193, asp-194, and ser-195 peptide bonds.\",\"PeriodicalId\":17268,\"journal\":{\"name\":\"Journal of The Chemical Society B: Physical Organic\",\"volume\":\"12 1\",\"pages\":\"2401-2406\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1971-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Chemical Society B: Physical Organic\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/J29710002401\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society B: Physical Organic","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/J29710002401","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The hydrolysis rate constant for acylchymotrypsins correlates with the rate constant for reaction of hydroxide ion with the ethyl esters (slope = 0·64, r= 0·867) over a wide range of structure variation in the acyl group. The low sensitivity to change of acyl group and to change in σ for benzoylchymotrypsins (ρ= 1·55, r= 0·952) is suggested to be due to electrophilic participation at the carbonyl oxygen of the acyl group. Tosylchymotrypsin is suggested as a model for the tetrahedral adduct of 4-methylbenzoylchymotrypsin with water and the electrophiles are identified as the NH groups of gly-193, asp-194, and ser-195 peptide bonds.
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