{"title":"评论:激活素和TGFβ在晚期结肠癌中使用分化的有丝分裂信号。","authors":"J. Bauer, Jonas J. Staudacher, N. Krett, B. Jung","doi":"10.29245/2572-9411/2016/1.1013","DOIUrl":null,"url":null,"abstract":"The TGFβ superfamily of ligands is defined by sequence homologies and consists of multiple members including TGFβ1, TGFβ2, TGFβ3, Activin A, Activin B, Activin AB, Nodal and BMPs (bone morphogenic protein)1. Signaling starts with ligand binding to a type II receptor, a serine/threonine receptor kinase, which catalyzes the phosphorylation of the associated type I receptor2,3. Each class of ligand binds to a specific type II receptor. TGFβ1 has a high affinity to the type I and type II receptor, whereas Activins are more promiscuous and are also able to bind BMP receptor type I4.","PeriodicalId":91764,"journal":{"name":"Journal of rare diseases research & treatment","volume":"28 1","pages":"43-45"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Commentary: Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer.\",\"authors\":\"J. Bauer, Jonas J. Staudacher, N. Krett, B. Jung\",\"doi\":\"10.29245/2572-9411/2016/1.1013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The TGFβ superfamily of ligands is defined by sequence homologies and consists of multiple members including TGFβ1, TGFβ2, TGFβ3, Activin A, Activin B, Activin AB, Nodal and BMPs (bone morphogenic protein)1. Signaling starts with ligand binding to a type II receptor, a serine/threonine receptor kinase, which catalyzes the phosphorylation of the associated type I receptor2,3. Each class of ligand binds to a specific type II receptor. TGFβ1 has a high affinity to the type I and type II receptor, whereas Activins are more promiscuous and are also able to bind BMP receptor type I4.\",\"PeriodicalId\":91764,\"journal\":{\"name\":\"Journal of rare diseases research & treatment\",\"volume\":\"28 1\",\"pages\":\"43-45\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of rare diseases research & treatment\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29245/2572-9411/2016/1.1013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of rare diseases research & treatment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29245/2572-9411/2016/1.1013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Commentary: Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer.
The TGFβ superfamily of ligands is defined by sequence homologies and consists of multiple members including TGFβ1, TGFβ2, TGFβ3, Activin A, Activin B, Activin AB, Nodal and BMPs (bone morphogenic protein)1. Signaling starts with ligand binding to a type II receptor, a serine/threonine receptor kinase, which catalyzes the phosphorylation of the associated type I receptor2,3. Each class of ligand binds to a specific type II receptor. TGFβ1 has a high affinity to the type I and type II receptor, whereas Activins are more promiscuous and are also able to bind BMP receptor type I4.
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