氯二氮环氧化物致地衣类药疹

Osamah Alkhuzaim
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引用次数: 1

摘要

地衣类药物反应是由IV型迟发性超敏反应引起的皮肤药疹。它通常发生在服用该药后的几个月到几年,其特征是紫色、扁平、多边形丘疹,对称地扩散到全身。我们报告一例26岁的女性,谁是氯二氮环氧化物治疗失眠,并提出了多个,环形,紫色,鳞状,发痒斑块在她的乳房。皮疹进展到累及大腿和颊黏膜,局部抗真菌药无效。皮肤活检显示扁平苔藓样淋巴细胞浸润。停药后3个月内皮肤出疹明显改善。据我们所知,这是首例对氯二氮环氧化物产生地衣类药物反应的病例报告。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lichenoid drug eruption induced by chlordiazepoxide
Lichenoid drug reaction is a cutaneous drug eruption due to a Type IV delayed hypersensitivity reaction. It usually occurs months to years following the intake of the drug and is characterized by purple, flat, polygonal papules that spread symmetrically and diffusely across the body. We report the case of a 26-year-old female, who was on chlordiazepoxide for the treatment of insomnia, and presented with multiple, annular, purple, scaly, itchy plaques over her breasts. The eruption progressed to involve the thighs and buccal mucosa and did not respond to topical antifungals. Skin biopsy revealed lichenoid lymphocytic infiltrate consistent with lichen planus. After discontinuation of chlordiazepoxide, her skin eruption significantly improved within 3 months. To our knowledge, this is the first case report of a patient who developed a lichenoid drug reaction to chlordiazepoxide.
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