顺势疗法对辐照大鼠唾液腺功能和形态的影响

P. N. B. Alencar, Luiza Lassi de Araújo Lopes, F. H. Neto, P. Venâncio, F. Groppo, G. Barbosa, Paulo Goberlânio de Barros Silva, R. L. Avelar
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摘要

目的:评价顺势疗法溶液对受辐射大鼠唾液功能和腮腺形态的辐射防护作用。材料与方法:取大鼠150只,随机分为6组。各组根据给药物质命名:对照组-生理盐水溶液;辐照对照:生理盐水溶液和15gy X射线;在15ch下活化的醇-氢醇溶液;辐照乙醇-氢醇溶液在15ch和15gy X辐射下的动力学研究顺势疗法- 0.25 ml (1mL/kg)辐照的氢酒精溶液,在15ch下动态;辐照的顺势疗法-顺势疗法溶液和15gy的X射线。每组根据安乐死时间点分为5个不同的亚组:12小时、3天、10天、17天和24天。放疗前7天和放疗后7天给药。在安乐死当天,用匹罗卡品诱导唾液分泌并收集。然后,这些动物被处死,腮腺被切除。结果:唾液功能分析显示,仅第17天顺势疗法放疗组与其他放疗组相比有统计学差异,其唾液流率更高。随着时间的推移,唯一一组在腺泡数量上有统计学显著差异的是辐照酒精组,它呈现出减少的趋势。结论:基于唾液功能和腮腺形态分析,顺势疗法溶液具有晚期放射防护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of homeopathy in the function and morphology of salivary parotid glands of irradiated rats
Objective : To evaluate the radioprotective effect of a homeopathic solution in salivary function and parotid glands morphology of irradiated rats. Materials and Methods : The sample consisted of 150 rats randomly divided into 6 groups. The groups were named based on the substance administered: Control- saline solution; Irradiated Control- saline solution and 15 Gy of X radiation; Alcohol-hydroalcoholic solution dynamized at 15 CH; Irradiated Alcohol- hydroalcoholic solution dynamized at 15 CH and 15 Gy of X radiation; Homeopathy- 0.25 ml (1mL/kg) of the irradiated hydroalcoholic solution and dynamized at 15 CH; Irradiated homeopathy- homeopathic solution and 15 Gy of X radiation. Each group was subdivided into 5 different subgroups, based on the time point of euthanasia: 12 hours, 3, 10, 17, and 24 days. The medication was administered for 7 days before and 7 days after the radiation treatment. On the day of euthanasia, salivation was induced with pilocarpine and collected. The animals were then sacrificed and the parotid glands were removed. Results : Salivary function analysis showed that only group irradiated homeopathy euthanized on day 17 had a statistically significant difference when compared to other irradiated groups, presenting a higher salivation flow rate. The only group that showed a statistically significant difference in the number of acini over time was the irradiated alcohol group, which presented a tendency of reduction. Conclusion: The homeopathic solution presented a late radioprotective effect based on salivary function and morphological analysis of the parotid gland.
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