藿香水浸膏的体内和体外愈合潜力conyzoïdes。适用于Wistar大鼠和人细胞的切除和切口创面

Christelle B.D. Kouloungous Bafila, Nadège Okémy Andissa, S. U. Moussoungou, B. Moulari, A. Abena
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引用次数: 0

摘要

以4、8 g/kg剂量的鹰嘴藤水提液和软膏对其愈合效果的影响。我们的研究对象是Wistar大鼠的追踪和切除性伤口。我们使用一些作者描述的经典试验对该植物的提取物和配方进行药理学工作和感官和毒理学分析。该方法得出的结果表明,该药膏均匀,弱芳香,呈酸性(pH值:5,6),富含溶解性和矿物质,急性剂量达3200mg /kg时未见致死性。此外,这种植物的水提取物含有丰富的黄酮类化合物。此外,还评价了鹰嘴草软膏对Wistar大鼠深创面的愈合作用。平面测量结果和测量超过二十六(26)天证明,药膏在4和8 g/大鼠体重;与阴性对照相比,400 mg/kg(参考产品)的Madecassol®显著减少了Wistar大鼠的平均深创面面积。此外,以5、5 ml/kg剂量给药于体外刮网细胞模型创面,24小时内可显著减少创面。此外,在剂量为11 ml/kg时,瘢痕形成完全,没有可见的伤口痕迹。这反映了与对照组相比,在划痕的水平上存在细胞推力,对照组的伤口几乎是张开的。由此,证实了文献资料和传统医学对spa的疗效总结。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vivo and in vitro healing potential of aqueous extract ointment Ageratum conyzoïdes Linn. applied to excision and incision wounds induced in Wistar rat and human cells
The healing effect of the aqueous extract and ointment at 4 and 8 g/kg doses of Ageratum conyzoides Linn. on tracing and excision-induced wounds in the Wistar rat was the subject of our study. We used the classical tests described by some authors to carry out pharmacological work and organoleptic and toxicological analyses of the extract and formulation of this plant. The results, derived from this methodology, show that this ointment is homogeneous, weakly aromatic and acidic (pH : 5,6), rich in dissolved and mineral substances, no lethality was observed up to the dose of 3200 mg/kg in acute. Also, the aqueous extract of this plant has an abundance of Flavonoids. In addition, the healing effect of Ageratum conyzoides L. ointment was evaluated on deep wounds in Wistar rats. The planimetry results and measurements made over twentysix (26) days proved that the ointment at 4 and 8 g/rat weight; Madecassol® at 400 mg/kg (reference product) significantly reduced the mean area of the deep wounds in Wistar rats compared to the negative controls. In addition, the aqueous extract of Ageratum conyzoides L. at the dose of 5,5 ml/kg administered in vitro on cell model wounds created by scraping the cell web, significantly reduces the wound in 24 hours. In addition, at the dose of 11 ml/kg this scarring is complete, there is no visible wound trace. This reflects the presence of a cell thrust at the level of the scratch compared to the control lot, whose wound remained almost gaping. Thus, are confirmed the data of literature and traditional medicine on spa summarized efficacy.
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