糖化白蛋白水平与妊娠期糖尿病的关系

Journal of Chittagong Medical College Teachers' Association Pub Date : 2021-12-31 DOI:10.3329/jcmcta.v32i2.66495

F. Islam, R. K. Kazal, Nadira Haque, N. Hosain, Badrunnahar Rumi, Keya Debnath, Ruma Akter, Marjiara Begum, Farhan Akhter

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摘要

背景:妊娠期糖尿病(GDM)是妊娠期间发现的一种常见的医学疾病，对母亲和胎儿的健康有不良影响。糖化血红蛋白(HbA1c)是糖尿病患者血糖控制的重要指标。但是，它只能反映长期血糖状态，不能反映短期血糖控制情况。也有研究表明，由于缺铁，妊娠期HbA1c不能准确反映血糖控制情况。但糖基化白蛋白(GA)反映2-3周内的平均血糖，不受缺铁的影响。因此，糖基化白蛋白可用于测量GDM患者近期血糖水平的变化。该研究的目的是评估糖基化白蛋白与GDM血糖状态的关系。材料与方法:本病例对照研究于2017年8月至2018年12月在达卡Bangabandhu Sheikh Mujib医科大学妇产科进行。共有140名年龄在18-35岁之间的孕妇在妊娠中期和晚期在室外产前诊所接受了这项研究。其中诊断为GDM的孕妇70例作为第一组，其余70例非糖尿病孕妇作为对照组和第二组。所有患者均测量了血浆糖化白蛋白。采用SPSS-22 (Statistical Packages for Social Sciences)软件对结果进行统计分析。结果:ⅰ组平均糖化白蛋白为17.12±2.00(%)，ⅱ组平均糖化白蛋白为12.90±1.03(%)。两组间差异有统计学意义(p<0.05)。GDM患者糖基化白蛋白(%)与75 gm葡萄糖后2小时呈正相关(r=0.643, p=0.001)。GDM患者GA与FBS之间也存在显著正相关(r=0.258, p=0.031)。结论:GDM患者血糖状态与母体糖基化白蛋白水平呈正相关。因此，糖基化白蛋白可用于反映妊娠期糖尿病孕妇的平均血糖状态。Jcmcta 2021;32 (2): 64-69

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Association of Glycosylated Albumin Level with Gestational Diabetes Mellitus

Background: Gestational Diabetes Mellitus (GDM) is a common medical disorder detected during pregnancy with adverse consequences on the health of the mother and the fetus. Glycosylated hemoglobin (HbA1c) is an important parameter of glycemic control in patients with diabetes mellitus. However, it only reflects the long-term glycemic status, but can’t reflect short term glycemic control. It has also been demonstrated that HbA1c does not reflect glycemic control accurately during pregnancy because of iron deficiency. But Glycosylated Albumin (GA) reflects average blood glucose within 2-3 weeks and is not influenced by iron deficiency. Therefore, glycosylated albumin may be used to measure recent changes in blood glucose level in GDM patients. The aim of the study is to evaluate the association of glycosylated albumin and glycemic status in GDM. Materials and methods: This case control study was carried out in the Department of Obstetrics & Gynecology, Bangabandhu Sheikh Mujib Medical University, BSMMU, Dhaka between August 2017 and December 2018. Atotal of 140 pregnant women between 18-35 years of age attending outdoor antenatal clinic in their second and third trimester of pregnancy were enrolled in this study. Among them 70 diagnosed case of GDM were considered as group I and rest 70 non-diabetic pregnant women were considered as control and group II. Plasma glycosylated albumin was measured in all of these patients. Statistical analysis of the results was obtained by using Windows based computer software devised with Statistical Packages for Social Sciences (SPSS-22). Results: The mean glycosylated albumin was 17.12±2.00 (%) in group I and 12.90±1.03 (%) in group II. The difference was statistically significant (p<0.05) between two groups. There was a positive significant moderate correlation (r=0.643, p=0.001) between glycosylated albumin (%) and 2 hours after 75 gm glucose in GDM patients. There was also a positive significant weak correlation (r=0.258, p=0.031) between GA and FBS in GDM patients. Conclusion: A significant positive association was found between glycemic status in GDM and maternal glycosylated albumin levels. Therefore,glycosylated albumin may be applied to reflect the average blood glucose status in pregnant women with GDM. JCMCTA 2021 ; 32 (2) : 64-69

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Journal of Chittagong Medical College Teachers' Association

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