一些新型腙基四唑衍生物的合成、表征及抗菌活性研究

IF 1 4区工程技术 Q4 CHEMISTRY, MULTIDISCIPLINARY

Iranian Journal of Chemistry & Chemical Engineering-international English Edition Pub Date : 2021-09-06 DOI:10.30492/IJCCE.2021.526860.4629

Z. A. Shuhaib, A. Sajjad

{"title":"一些新型腙基四唑衍生物的合成、表征及抗菌活性研究","authors":"Z. A. Shuhaib, A. Sajjad","doi":"10.30492/IJCCE.2021.526860.4629","DOIUrl":null,"url":null,"abstract":"In this investigation, a combination of Z1-Z5 hydrazone compounds is obtained from the reaction between 4-methylbenzohydrazide and aryl-aldehydes. Subsequent unique synthetic approach to the preparation of di-substituted tetrazoles T6-T10 was achieved through a 1,3- dipolar cycloaddition of sodium azide and prepared hydrazone compounds in ethyl alcohol. Results have been verified by Fourier-transform infrared spectroscopy (FTIR), 1H and 13C-nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activity of anti-microbial screening has shown that (Z1–Z6 and T10) presented antifungal activity. The other tested Z2 compound was found to exhibit good antibacterial activity, while the other tested compounds revealed low antibacterial activity.","PeriodicalId":14572,"journal":{"name":"Iranian Journal of Chemistry & Chemical Engineering-international English Edition","volume":"39 1","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Characterization and Antimicrobial Activity of Some New Tetrazole Derivatives from Hydrazones\",\"authors\":\"Z. A. Shuhaib, A. Sajjad\",\"doi\":\"10.30492/IJCCE.2021.526860.4629\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this investigation, a combination of Z1-Z5 hydrazone compounds is obtained from the reaction between 4-methylbenzohydrazide and aryl-aldehydes. Subsequent unique synthetic approach to the preparation of di-substituted tetrazoles T6-T10 was achieved through a 1,3- dipolar cycloaddition of sodium azide and prepared hydrazone compounds in ethyl alcohol. Results have been verified by Fourier-transform infrared spectroscopy (FTIR), 1H and 13C-nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activity of anti-microbial screening has shown that (Z1–Z6 and T10) presented antifungal activity. The other tested Z2 compound was found to exhibit good antibacterial activity, while the other tested compounds revealed low antibacterial activity.\",\"PeriodicalId\":14572,\"journal\":{\"name\":\"Iranian Journal of Chemistry & Chemical Engineering-international English Edition\",\"volume\":\"39 1\",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2021-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Chemistry & Chemical Engineering-international English Edition\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.30492/IJCCE.2021.526860.4629\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Chemistry & Chemical Engineering-international English Edition","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.30492/IJCCE.2021.526860.4629","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

在本研究中，4-甲基苯并肼与芳基醛反应得到Z1-Z5腙化合物的组合。随后，通过叠氮化钠的1,3-偶极环加成和在乙醇中制备的腙化合物，实现了制备二取代四唑T6-T10的独特合成方法。利用傅里叶变换红外光谱(FTIR)、核磁共振(NMR)和质谱分析对结果进行了验证。抑菌活性筛选表明(Z1-Z6和T10)具有抑菌活性。Z2化合物表现出较好的抑菌活性，其他化合物表现出较低的抑菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis, Characterization and Antimicrobial Activity of Some New Tetrazole Derivatives from Hydrazones

In this investigation, a combination of Z1-Z5 hydrazone compounds is obtained from the reaction between 4-methylbenzohydrazide and aryl-aldehydes. Subsequent unique synthetic approach to the preparation of di-substituted tetrazoles T6-T10 was achieved through a 1,3- dipolar cycloaddition of sodium azide and prepared hydrazone compounds in ethyl alcohol. Results have been verified by Fourier-transform infrared spectroscopy (FTIR), 1H and 13C-nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activity of anti-microbial screening has shown that (Z1–Z6 and T10) presented antifungal activity. The other tested Z2 compound was found to exhibit good antibacterial activity, while the other tested compounds revealed low antibacterial activity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Iranian Journal of Chemistry & Chemical Engineering-international English Edition CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

2.80

自引率

22.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of the Iranian Journal of Chemistry and Chemical Engineering is to foster the growth of educational, scientific and Industrial Research activities among chemists and chemical engineers and to provide a medium for mutual communication and relations between Iranian academia and the industry on the one hand, and the world the scientific community on the other.