苦瓜籽和芦荟凝胶粉对大鼠的抗糖尿病作用

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摘要

糖尿病是全球第四大死因。以饮食为基础的治疗各种健康失调的方法被认为是安全、经济和可持续的。补充和替代医学(CAM)是世界范围内用于糖尿病患者管理的方法之一。本研究旨在达到以下目的:分析苦瓜籽(BMS)和芦荟凝胶(AVG)粉末的近因和矿物质含量;利用不同浓度的粉末及其成分分析来开发功能性鸡块,并探讨粉末在协同作用下的抗糖尿病潜力。根据消费者的接受程度,选择1个对照和2个配方,通过30天的动物模型进行疗效试验。为此,将18只糖尿病大鼠随机分为3组。各组分为阳性对照组(G0,正常饮食)和另外2个不同AVG和BMS粉的组。G1组每天饲喂50% BMS和50% AVG粉,G2组每天饲喂75% BMS和25% AVG粉。G1组的空腹血糖水平、糖化血红蛋白、胆固醇、低密度脂蛋白胆固醇、尿素氮和尿酸水平显著降低,而G2组的胰岛素、高密度脂蛋白胆固醇和甘油三酯水平有所改善,而随着时间的推移,血糖水平得到了更好的控制。补充BMS和AVG有助于控制高血糖和相关并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-Diabetic Impact of Momordica Charantia Seed and Aloe Barbadensis Miller Gel Powder in Sprague Dawley Rats
Diabetes mellitus is the 4th leading cause of death worldwide. Diet-based approaches to treating various health disorders are considered safe, economical, and sustainable. Complementary and alternative medicine (CAM) is one of the methods used worldwide for the management of diabetes millets. The present study was designed to achieve the following objectives: to analyze bitter melon seed (BMS) and aloe vera gel (AVG) powder for proximate and mineral content; to develop functional chicken nuggets by using various concentrations of both powdered and their compositional analyses and to probe the antidiabetic potential of powders in synergy. A control and two formulations were selected, based on consumer acceptability, for efficacy trial through the animal model of 30 days. For this purpose, 18 diabetic Sprague Dawley Rats were randomly divided into 3 groups. The groups included the positive control group (G0, normal diet) and two other groups with different AVG and BMS powder. G1 group received 50% BMS and 50% AVG powder whereas, G2 was fed on 75% BMS and 25% AVG powder per day. G1 showed a significant reduction in fasting blood glucose level, glycated hemoglobin, cholesterol, LDL-Cholesterol, blood urea nitrogen, and uric acid, whereas the G2 showed improvement in insulin, HDL-Cholesterol, and triglycerides levels whereas showed better control over time. Supplementation of BMS and AVG can help to control hyperglycemia and related complications.
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