{"title":"铱(I)和相转移催化氟化钾在氧化铝上的氢转移还原","authors":"Yuri Goldberg, Howard Alper","doi":"10.1016/0304-5102(94)00067-0","DOIUrl":null,"url":null,"abstract":"<div><p>The hydrogen transfer reduction of alkyl aryl (heteroaryl) ketones readily occurs at 82°C in a solid—liquid biphasic system when using 2-propanol as hydrogen donor, potassium fluoride on alumina (50 wt.%) as a base, [Ir(COD)Cl]<sub>2</sub> as the metal catalyst and 18-crown-6 as the phase-transfer agent. The molar ratio of ketone : [Ir] : F<sup>−</sup>] : 18-crown-6 was 200:1:5:2. A number of alkyl aryl, and alkyl heteroaryl carbinols have been prepared in 73–84% isolated yield under HTR-PTC conditions.</p></div>","PeriodicalId":16567,"journal":{"name":"分子催化","volume":"92 2","pages":"Pages 149-153"},"PeriodicalIF":0.0000,"publicationDate":"1994-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0304-5102(94)00067-0","citationCount":"5","resultStr":"{\"title\":\"Iridium (I) and phase-transfer catalyzed hydrogen-transfer reduction of ketones using potassium fluoride on alumina as a base\",\"authors\":\"Yuri Goldberg, Howard Alper\",\"doi\":\"10.1016/0304-5102(94)00067-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The hydrogen transfer reduction of alkyl aryl (heteroaryl) ketones readily occurs at 82°C in a solid—liquid biphasic system when using 2-propanol as hydrogen donor, potassium fluoride on alumina (50 wt.%) as a base, [Ir(COD)Cl]<sub>2</sub> as the metal catalyst and 18-crown-6 as the phase-transfer agent. The molar ratio of ketone : [Ir] : F<sup>−</sup>] : 18-crown-6 was 200:1:5:2. A number of alkyl aryl, and alkyl heteroaryl carbinols have been prepared in 73–84% isolated yield under HTR-PTC conditions.</p></div>\",\"PeriodicalId\":16567,\"journal\":{\"name\":\"分子催化\",\"volume\":\"92 2\",\"pages\":\"Pages 149-153\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0304-5102(94)00067-0\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"分子催化\",\"FirstCategoryId\":\"1089\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0304510294000670\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Chemical Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"分子催化","FirstCategoryId":"1089","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0304510294000670","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Chemical Engineering","Score":null,"Total":0}
Iridium (I) and phase-transfer catalyzed hydrogen-transfer reduction of ketones using potassium fluoride on alumina as a base
The hydrogen transfer reduction of alkyl aryl (heteroaryl) ketones readily occurs at 82°C in a solid—liquid biphasic system when using 2-propanol as hydrogen donor, potassium fluoride on alumina (50 wt.%) as a base, [Ir(COD)Cl]2 as the metal catalyst and 18-crown-6 as the phase-transfer agent. The molar ratio of ketone : [Ir] : F−] : 18-crown-6 was 200:1:5:2. A number of alkyl aryl, and alkyl heteroaryl carbinols have been prepared in 73–84% isolated yield under HTR-PTC conditions.
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