低分子量透明质酸、高分子量透明质酸、透明质酸酶对Balb/C小鼠宫颈早孕模型的影响

IF 0.2 Q4 PHARMACOLOGY & PHARMACY
Fikhy rizky Hapsari, Suheni Ninik Hariyati, I. Wiyasa, Teguh Wiyono, Dewi Santosaningsih
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引用次数: 0

摘要

前言:感染是早产的最大原因,约占25-40%,经阴道上行感染是最常见的感染途径。本研究旨在探讨感染大肠杆菌模型小鼠Balb/c早产后低分子量透明质酸(LMWHA)、高分子量透明质酸(HMWHA)水平及透明质酸酶水平的变化。方法:本研究采用在实验室进行的实际实验设计,对暴露于大肠杆菌的balb/c小鼠进行体内实验,随机后验,仅设对照组设计。以109 CFU/ml暴露于大肠杆菌balb/c小鼠子宫颈的早产模型,取子宫颈标本,分光光度法测定低分子量华(LMWHA)、低分子量华(HMWHA)和透明质酸酶(hyaluronidase)水平。本研究分为两组。对照组和治疗组。结果:暴露于大肠杆菌的早熟Balb/C宫颈小鼠低分子量透明质酸(LMWHA)和透明质酸酶的水平高于Balb/C宫颈小鼠。结论:大肠杆菌感染小鼠模型子宫颈高分子量透明质酸和透明质酸酶升高,高分子量透明质酸降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Exposure to Escherichia coli with Low Molecular Weight Hyaluronan, High Molecular Weight Hyaluronan, Hyaluronidase in the Cervix Premature Pregnant Model of Balb/C Mice
Introduction: Infection is the biggest cause of preterm labor, about 25-40%, and ascending infection through the vagina is the most common route of infection. This study aims to evaluate the level of Low Molecular Weight Hyaluronan (LMWHA), level of High Molecular Weight Hyaluronan (HMWHA), and the level of the enzyme hyaluronidase in Balb/c premature labor due to infection with Escherichia coli model mice. Methods: This study used an actual experimental design carried out in the laboratory in vivo on balb/c mice exposure to Escherichia coli with a randomized post-test only with a control group design. In the premature model of exposure to Escherichia coli balb/c mice on the cervix of 109 CFU/ml, cervical samples were taken and the levels of LMWHA, HMWHA, and hyaluronidase were measured using spectrophotometry. This study was divided into 2 groups. Control group and treatment group. Results: Low Molecular Weight Hyaluronan (LMWHA) and of the hyaluronidase enzyme levels in premature Balb/C cervical mice exposed to E. coli were higher than in Balb/C cervical mice. High Molecular Weight Hyaluronan (HMWHA) levels in premature Balb/C cervical mice exposed to E. coli were lower Conclusion: In the cervix of the infected by E. coli mice model, LMWHA and hyaluronidase enzymes increased and HMWHA decreased.    
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