一些具有药用价值的新噻唑衍生物的合成

Sulfur Letters Pub Date : 2003-06-01 DOI:10.1080/0278611031000095331

S. El-Desoky, S. Bondock, H. Etman, A. Fadda, M. Metwally

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引用次数: 37

摘要

1,3-噻唑烷酮衍生物1a-c与不同芳香醛和/或芳基重氮氯缩合得到相应的芳烯2-10和芳基1,3-噻唑烷酮12-20。12的溴化生成二溴衍生物21。用hcho -哌啶处理1a-c得到曼尼希加合物24。化合物1a经羟甲基化、氧化和甲酰化得到产物25-28。新产物的结构通过光谱和分析方法得到了证实。

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Synthesis of some new thiazole derivatives of pharmaceutical interest

Condensation of 1,3-thiazolidinone derivatives 1a-c with different aromatic aldehydes and/or aryldiazonium chlorides gave the corresponding arylidenes 2-10 and arylazo-1,3-thiazolidinones 12-20. Bromination of 12 resulted in the formation of dibromo derivative 21. Treatment of 1a-c with HCHO-piperidine gave the Mannich adduct 24. Compound 1a was hydroxymethylated, oxidized and formylated to yield the products 25-28. The structures of the new products were confirmed by spectral and analytical methods.

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Sulfur Letters

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