{"title":"1,2-二氢吡啶-3-碳腈新化合物的合成、表征及生物活性研究","authors":"H. Ibraheem, Y. Al-Majedy, A. Salim, R. Al-Bayati","doi":"10.22401/JNUS.21.2.07","DOIUrl":null,"url":null,"abstract":"New 1,2-dihydropyridine-3-carbonitrile derivative compounds (3,4) were synthesized by cyclization of ketones (compound (1) and compound (2)) with appropriate aldehydes (4-N, Ndimethylaminobenzaldehyde and 4-chloro-2-oxo-2H-chromene-3-carbaldehyde) in presence of ethyl cyano acetate and ammonium acetate. The new synthesized compounds have been characterized using Melting point, FT-IR spectroscopy and 1 H-NMR and 13 C-NMR spectrum. The evaluation of biological activity of some synthesized compounds (1-4) with different concentration 10 mg mL −1 , 1 mg mL −1 and 0.1 mg mL −1 , against two types of bacteria on gram positive bacterial Staphylococcus aureus, Streptococcus pyogenus and gram nagetive bacterial Escherichia coli, Klebsiella pneumniae. [DOI: 10.22401/JNUS.21.2.07]","PeriodicalId":14922,"journal":{"name":"Journal of Al-Nahrain University-Science","volume":"59 22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity\",\"authors\":\"H. Ibraheem, Y. Al-Majedy, A. Salim, R. Al-Bayati\",\"doi\":\"10.22401/JNUS.21.2.07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"New 1,2-dihydropyridine-3-carbonitrile derivative compounds (3,4) were synthesized by cyclization of ketones (compound (1) and compound (2)) with appropriate aldehydes (4-N, Ndimethylaminobenzaldehyde and 4-chloro-2-oxo-2H-chromene-3-carbaldehyde) in presence of ethyl cyano acetate and ammonium acetate. The new synthesized compounds have been characterized using Melting point, FT-IR spectroscopy and 1 H-NMR and 13 C-NMR spectrum. The evaluation of biological activity of some synthesized compounds (1-4) with different concentration 10 mg mL −1 , 1 mg mL −1 and 0.1 mg mL −1 , against two types of bacteria on gram positive bacterial Staphylococcus aureus, Streptococcus pyogenus and gram nagetive bacterial Escherichia coli, Klebsiella pneumniae. [DOI: 10.22401/JNUS.21.2.07]\",\"PeriodicalId\":14922,\"journal\":{\"name\":\"Journal of Al-Nahrain University-Science\",\"volume\":\"59 22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Al-Nahrain University-Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22401/JNUS.21.2.07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Al-Nahrain University-Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22401/JNUS.21.2.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity
New 1,2-dihydropyridine-3-carbonitrile derivative compounds (3,4) were synthesized by cyclization of ketones (compound (1) and compound (2)) with appropriate aldehydes (4-N, Ndimethylaminobenzaldehyde and 4-chloro-2-oxo-2H-chromene-3-carbaldehyde) in presence of ethyl cyano acetate and ammonium acetate. The new synthesized compounds have been characterized using Melting point, FT-IR spectroscopy and 1 H-NMR and 13 C-NMR spectrum. The evaluation of biological activity of some synthesized compounds (1-4) with different concentration 10 mg mL −1 , 1 mg mL −1 and 0.1 mg mL −1 , against two types of bacteria on gram positive bacterial Staphylococcus aureus, Streptococcus pyogenus and gram nagetive bacterial Escherichia coli, Klebsiella pneumniae. [DOI: 10.22401/JNUS.21.2.07]
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
