On the use of a peak deconvolution procedure for the determination of energy barrier to enantiomerization in dynamic chromatography

Manual or computer assisted peak deconvolution on chromatograms of the racemate of 1-chloro-2,2-dimethylaziridine enantiomers GC was used to determine the peak areas of enantiomers in the racemate prior ( AA,0, AB,0) and after the separation (AA, AB). These peak areas were used in the determination of apparent rate constants and apparent energy barrier to enantiomer- ization. Comparison of apparent energy barriers determined using deconvolution of chromatograms with data published in liter- ature showed differences within 7 % rel.