从慢性鼻炎到死亡:鼻息肉治疗的致命结果

D. Mayer , A. Lukic , V. Petrovecki , M. Bakovic , D. Strinovic , J. Skavic
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引用次数: 1

摘要

鼻息肉病(NP)被认为是鼻黏膜和鼻窦的慢性炎症状态,表现为各种鼻症状。在大多数情况下,它是保守治疗。近年来,功能性内窥镜鼻窦手术(FESS)成为治疗NP的一种有价值和优势的手术方法。尽管该手术存在遗传风险,但与对患者的潜在益处相比,其并发症发生率被认为是可以接受的。病例55岁男性因手术切除鼻息肉入院。在常规术前程序后,患者接受FESS。全麻下,打开左侧蝶窦,清除炎性分泌物,切除息肉,钻孔后左侧上颌窦引流。对息肉及鼻黏膜切片进行病理组织学分析,诊断为鼻窦内翻性乳头状瘤。术后早期恢复正常,术后2 h患者开始逐渐失去意识,进入昏迷状态。头部CT及血管造影显示:颅内气肿,左侧筛窦缺损,左侧脑额叶血肿,四个脑室出血。在接下来的8天里进行了一系列神经外科手术。尽管尝试解决上述并发症,但患者仍处于昏迷状态,并在息肉切除术后16天死亡。尸检显示在颅底左侧筛骨筛板左侧后段有广泛的卵圆形缺损。脑肿胀严重充血,左侧额叶基底面蛛网膜下腔出血。额叶连续切片显示左侧额叶基底脑室周围结构的大脑内血肿,延伸至整个脑室系统。除此之外,最突出的发现是双侧支气管肺炎。死因是脑外伤后的支气管肺炎,死亡方式为暴力。结论慢性鼻窦炎或NP患者经内镜手术后大部分恢复良好,但不可忽视其不良后果的可能性。这个案件要求对医疗事故造成的潜在医疗责任进行评估。考虑到慢性鼻窦炎和NP的高患病率,应该仔细分析术后死亡的法律方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From chronic rhinitis to death: Fatal outcome of nasal polyposis treatment

Introduction

Nasal polyposis (NP) is considered to be the state of chronic inflammation of nasal mucosa and sinuses presenting with various nasal symptomatology. In most cases, it is treated conservatively. Recently, functional endoscopic sinus surgery (FESS) was developed as the valuable and advantageous surgical procedure to treat NP. Despite the inherited risks of this procedure, its complication rate is considered to be acceptable compared to potential benefits for the patient.

Case

Fifty-five-year-old man was admitted to the hospital for surgical removal of the nasal polypus. After the usual pre-surgery procedures, the patient underwent FESS. Under general anesthesia, left sphenoid sinus was opened and cleaned from the imflammatory discharge, polypus was excised, and following the trepanation the left maxillary sinus was left to drain out. Polypus and pieces of sinonasal mucosa were sent to pathohistological analysis, which yielded in diagnosis of inverted sinonasal papilloma.

The early postoperative recovery was regular, but 2 h upon the surgery, the patient started to lose consciousness gradually falling into the state of coma. CT scan and angiography of the head revealed pneumocranium, defect of the left ethmoidal sinus, hematoma in the left frontal cerebral lobe, as well as the hemorrhage in all four cerebral ventricles. A series of neurosurgical procedures followed in the next 8 days. Despite the attempts to resolve above complications, the patient remained comatous and died 16 days after the polypectomy.

Autopsy revealed the extensive oval-shaped defect on the skull base in the left posterior part of cribrous plate of the left ethmoid bone. The brain appeared swollen and heavily congested, showing the zone of subarachnoidal hemorrhage in basal face of left frontal lobe. Frontal serial sections revealed large intracerebral haematoma in basal periventricular structures of left frontal lobe extending to the whole ventricular system. Apart from the above, most prominent finding was bilateral bronchopneumonia. The cause of death was attributed to bronchopneumonia following the brain trauma, manner of death ruled as violent.

Conclusion

Although majority of the patients suffering from chronic rhinosinusitis or NP recover well after the endoscopic surgery, the possibility of undesirable outcome must not be ignored. This case calls for assessment of potential medical liability caused by malpractice. Having in mind rather high prevalence of chronic rhinosinusitis and NP, legal aspects of postoperative death should be carefully analyzed.

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