F. Eisenhaber, Chandra Verma, T. Blundell
{"title":"In memoriam of Narayanaswamy Srinivasan (1962–2021)","authors":"F. Eisenhaber, Chandra Verma, T. Blundell","doi":"10.1002/prot.26287","DOIUrl":null,"url":null,"abstract":"The devastating, unexpected news of Prof. Narayanaswamy Srinivasan, a world-renowned pioneer in structural computational biology, genomics, and biophysics, passing away on September 3, 2021, spread among the international scientific community within hours. We mourn not only the loss of a super-engaged, creative scientist with a sharp mind but also the loss of a teacher for numerous PhD students and postdocs who made a career after their time with him and of an influential voice in the Indian academic system always defending the importance and the needs of science and its benefits for society. N. Srinivasan was an unusual man. He had the extraordinary gift to win people over, to see and to emphasize the common interest, to let his colleagues feel appreciated and convenient with him. This is not a little achievement in the generally very competitive scientific community that is overpopulated with very personal success-oriented or borderline personalities (maybe, as a side effect of the constant demand for creativity). For his wide, international circle of close friends and colleagues, he was Srini, the sanguine, friendly smiling scientist with a neverending interest in scientific discovery. For those who encountered him first at later stages of his life, he was always seen together with his lovely life companion Mini (Prof. Ramanathan Sowdhamini, currently at NCBS, Bangalore). Mini and Srini were the epitome of a scientific couple, both being impactful in their own right but most effective together. His family was very important to him. His joy did not know any bounds when, in 1996, his daughter Jayashree (currently studying biotechnology) was born. Srini was often preoccupied in being social with his friends and colleagues and playful (yes, also playing computer games or enjoying watching cricket games, sometimes, much to the annoyance of his fiancé!). He liked to share breakfast, typically starting at 8 a.m., with guests, all the time gossiping away on the lives, trials, and tribulations of acquaintances, some scientific discovery, or usually him excitedly discussing a recent discovery made in his lab. This routine had a very funny ending, which was usually around 9 a.m., when he would suddenly look at his watch with horror and with that warm smile admonish himself for leaving too late and rush off to catch the bus that would ferry him to his office at the Indian Institute of Science. Narayanaswamy Srinivasan was born on April 1, 1962 (at Government Kasturba Gandhi Hospital for Women and Children in Triplicane, Chennai/Tamil Nadu) to late Mr. K. Narayanaswamy and Ms. N. Jayalakshmi as the youngest child to a family of eight children. Maybe, being born on April Fools' Day had forever inserted the sense for humor and joke into him. As a young boy, Srinivasan was very sports-oriented and enjoyed playing cricket. His high schooling was in Rajah Muthiah Higher Secondary School (in Raja Annamalai Puram, Chennai) during the years 1976–1979. He earned his Bachelor's degree in Physics (1979–1982) at Jain College, Chennai. He was known to spend long hours tutoring mathematics to younger students. The Biophysics Department of Madras University granted him the Master's degree (1982–1984). The Madras School and Biophysics Department are much renowned as the birthplace of many works of late Prof. G.N. Ramachandran (GNR). To make matters follow, Srinivasan joined late Prof. C. Ramakrishnan's (CR) laboratory at the Molecular Biophysics Unit (MBU) of Indian Institute of Science (IISc), Bangalore, in 1984. Also, during his PhD, he successfully collaborated with Prof. Padmanabhan Balaram, a noted biochemist and Padma Bhushan award recipient. In 1991, he was awarded the PhD for his thesis “Conformational studies on globular proteins: Data analysis”. To note, CR, as he is fondly called, had worked on the Ramachandran plot project together with GNR. Thus, Srinivasan has been brought up in this famous legacy of genuinely Indian-born science. He was always highly passionate and excited about his recent works on revisiting the Ramachandran map as well as about the collaboration with CR, his PhD guru. Whereas the backbone dihedral angle calculations were done manually in the early work, it was redone using computers also accounting for possible deviations from ideal bond length and bond angle parameters of the peptide unit. Such a reexamination provided a stereochemical rationale, as conceptualized by Srinivasan, for why certain regions of the Ramachandran map areas albeit “disallowed,” using ideal internal parameters, are actually tolerated in protein structures. Srinivasan's joy knew no bounds when this work of four generations—GNR, CR, N. Srinivasan, and his students' and coworkers' publications—was accepted in reputed journals and gained international attention. His postdoctoral period was very intensive. After having been a senior research fellow at IISc (in the group of Prof. Balaram) for 10 months, he moved to Tom Blundell's lab at Birkbeck College London (1991–1994). Together with Mini, Srini spent most of the time, even on weekends, in the lab. Srini used to engage in conversation with Prof. Tom Blundell on new and newer projects. Tom started getting quite worried if the couple may not be having enough relaxing time and he had secret ploys to get them walk along the banks of Thames River and listen to opera music in theaters. For the following 2 years, N. Srinivasan accepted an offer from Mike Waterfield at the Ludwig Institute for Cancer Research in London. From 1996 to 1998, he was reunited with Tom Blundell who had moved to the Department of Biochemistry of Cambridge University. Srinivasan left Received: 18 November 2021 Accepted: 22 November 2021","PeriodicalId":20789,"journal":{"name":"Proteins: Structure","volume":"28 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proteins: Structure","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/prot.26287","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

摘要

世界著名的结构计算生物学、基因组学和生物物理学先驱Narayanaswamy Srinivasan教授于2021年9月3日去世,这一噩耗在数小时内就传遍了国际科学界。我们不仅哀悼失去了一位高度投入、富有创造力、思维敏锐的科学家,也哀悼失去了一位老师,许多博士生和博士后在跟随他之后走上了自己的职业生涯,也哀悼失去了一位在印度学术体系中始终捍卫科学的重要性、需求及其对社会的益处的有影响力的声音。斯里尼瓦桑是一个不寻常的人。他有一种非凡的才能来赢得人们的支持,看到并强调共同的利益,让他的同事感到被欣赏,和他在一起很方便。在普遍竞争激烈的科学界,这不是一个小成就,因为科学界充斥着非常注重个人成功或边缘性人格的人(也许,这是对创造力不断需求的副作用)。在他广泛的国际朋友和同事圈子里,他是斯里尼,一个乐观、友好、微笑的科学家,对科学发现有着永无止境的兴趣。对于那些在他生命后期第一次遇到他的人来说,他总是和他可爱的生活伴侣Mini (Ramanathan Sowdhamini教授,目前在班加罗尔的NCBS)在一起。Mini和Srini是一对科学夫妇的缩影,他们各自都很有影响力,但最有效的是一起。他的家庭对他来说非常重要。1996年,当他的女儿贾亚什丽(Jayashree,目前正在学习生物技术)出生时,他的喜悦无法抑制。斯里尼经常全神贯注于与朋友和同事的社交活动,玩得很开心(是的,他也玩电脑游戏或看板球比赛,有时这让他的未婚妻很恼火!)他喜欢和客人一起分享早餐,通常从早上8点开始,一直在八卦熟人的生活、考验和磨难,一些科学发现,或者通常是他兴奋地讨论他实验室里最近的发现。这个例行公事有一个非常有趣的结局,通常是在上午9点左右,他会突然惊恐地看着手表,带着温暖的微笑告诫自己离开得太晚了,然后匆匆赶去坐公共汽车,把他送到他在印度科学研究所的办公室。Narayanaswamy Srinivasan于1962年4月1日出生(在金奈/泰米尔纳德邦Triplicane的Kasturba Gandhi妇幼医院),已故的K. Narayanaswamy先生和N. Jayalakshmi女士是家中八个孩子中最小的孩子。也许,出生在愚人节让他永远有了幽默和开玩笑的感觉。作为一个小男孩,斯里尼瓦桑非常喜欢运动,喜欢打板球。1976年至1979年,他在Raja Muthiah高中(Raja Annamalai Puram, Chennai)接受高中教育。他在金奈耆那学院获得物理学学士学位(1979-1982)。众所周知,他会花很长时间给年纪较小的学生辅导数学。1982-1984年获马德拉斯大学生物物理系硕士学位。马德拉斯学院和生物物理系是著名的已故教授G.N.拉马钱德兰(GNR)的许多作品的诞生地。为了进一步发展,斯里尼瓦桑于1984年加入了班加罗尔印度科学研究所分子生物物理单元(MBU)已故教授C. Ramakrishnan的实验室。此外,在他的博士学位期间,他成功地与Padmanabhan Balaram教授合作,Padmanabhan教授是一位著名的生物化学家和Padma Bhushan奖获得者。1991年,以论文《球状蛋白的构象研究:数据分析》获得博士学位。值得注意的是,CR(人们亲切地称呼他)曾与GNR一起参与拉马钱德兰地块项目。因此,斯里尼瓦桑是在这个著名的真正的印度出生的科学遗产中长大的。他对自己最近重新审视拉马钱德兰地图的工作,以及与他的博士导师CR的合作,总是充满激情和兴奋。而在早期的工作中,主二面角的计算是手工完成的,它是用计算机重新完成的,也考虑到肽单元的理想键长和键角参数可能存在的偏差。这样的重新检查提供了立体化学的基本原理,正如Srinivasan概念化的那样,为什么Ramachandran的某些区域虽然使用理想的内部参数“不允许”,但实际上在蛋白质结构中是可以容忍的。当四代人——gnr、CR、n·斯里尼瓦桑,以及他的学生和同事的出版物——的工作被知名期刊接受并获得国际关注时,斯里尼瓦桑的喜悦是无止境的。他的博士后时期非常紧张。在印度科学院(IISc)担任高级研究员之后。 1991-1994年,他搬到了伦敦伯克贝克学院汤姆·布伦德尔的实验室。斯里尼和米尼一起在实验室里度过了大部分时间,甚至周末也是如此。斯里尼过去常常与汤姆·布伦德尔教授就新的和更新的项目进行交谈。汤姆开始担心这对夫妇是否没有足够的放松时间,于是他想出了一个秘密的办法,让他们沿着泰晤士河散步,在剧院里听歌剧。在接下来的两年里,N. Srinivasan接受了伦敦路德维希癌症研究所Mike Waterfield的邀请。从1996年到1998年,他与搬到剑桥大学生物化学系的汤姆·布伦德尔(Tom Blundell)重逢。接收日期:2021年11月18日接收日期:2021年11月22日 1991-1994年,他搬到了伦敦伯克贝克学院汤姆·布伦德尔的实验室。斯里尼和米尼一起在实验室里度过了大部分时间,甚至周末也是如此。斯里尼过去常常与汤姆·布伦德尔教授就新的和更新的项目进行交谈。汤姆开始担心这对夫妇是否没有足够的放松时间,于是他想出了一个秘密的办法,让他们沿着泰晤士河散步,在剧院里听歌剧。在接下来的两年里,N. Srinivasan接受了伦敦路德维希癌症研究所Mike Waterfield的邀请。从1996年到1998年,他与搬到剑桥大学生物化学系的汤姆·布伦德尔(Tom Blundell)重逢。接收日期:2021年11月18日接收日期:2021年11月22日
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In memoriam of Narayanaswamy Srinivasan (1962–2021)
The devastating, unexpected news of Prof. Narayanaswamy Srinivasan, a world-renowned pioneer in structural computational biology, genomics, and biophysics, passing away on September 3, 2021, spread among the international scientific community within hours. We mourn not only the loss of a super-engaged, creative scientist with a sharp mind but also the loss of a teacher for numerous PhD students and postdocs who made a career after their time with him and of an influential voice in the Indian academic system always defending the importance and the needs of science and its benefits for society. N. Srinivasan was an unusual man. He had the extraordinary gift to win people over, to see and to emphasize the common interest, to let his colleagues feel appreciated and convenient with him. This is not a little achievement in the generally very competitive scientific community that is overpopulated with very personal success-oriented or borderline personalities (maybe, as a side effect of the constant demand for creativity). For his wide, international circle of close friends and colleagues, he was Srini, the sanguine, friendly smiling scientist with a neverending interest in scientific discovery. For those who encountered him first at later stages of his life, he was always seen together with his lovely life companion Mini (Prof. Ramanathan Sowdhamini, currently at NCBS, Bangalore). Mini and Srini were the epitome of a scientific couple, both being impactful in their own right but most effective together. His family was very important to him. His joy did not know any bounds when, in 1996, his daughter Jayashree (currently studying biotechnology) was born. Srini was often preoccupied in being social with his friends and colleagues and playful (yes, also playing computer games or enjoying watching cricket games, sometimes, much to the annoyance of his fiancé!). He liked to share breakfast, typically starting at 8 a.m., with guests, all the time gossiping away on the lives, trials, and tribulations of acquaintances, some scientific discovery, or usually him excitedly discussing a recent discovery made in his lab. This routine had a very funny ending, which was usually around 9 a.m., when he would suddenly look at his watch with horror and with that warm smile admonish himself for leaving too late and rush off to catch the bus that would ferry him to his office at the Indian Institute of Science. Narayanaswamy Srinivasan was born on April 1, 1962 (at Government Kasturba Gandhi Hospital for Women and Children in Triplicane, Chennai/Tamil Nadu) to late Mr. K. Narayanaswamy and Ms. N. Jayalakshmi as the youngest child to a family of eight children. Maybe, being born on April Fools' Day had forever inserted the sense for humor and joke into him. As a young boy, Srinivasan was very sports-oriented and enjoyed playing cricket. His high schooling was in Rajah Muthiah Higher Secondary School (in Raja Annamalai Puram, Chennai) during the years 1976–1979. He earned his Bachelor's degree in Physics (1979–1982) at Jain College, Chennai. He was known to spend long hours tutoring mathematics to younger students. The Biophysics Department of Madras University granted him the Master's degree (1982–1984). The Madras School and Biophysics Department are much renowned as the birthplace of many works of late Prof. G.N. Ramachandran (GNR). To make matters follow, Srinivasan joined late Prof. C. Ramakrishnan's (CR) laboratory at the Molecular Biophysics Unit (MBU) of Indian Institute of Science (IISc), Bangalore, in 1984. Also, during his PhD, he successfully collaborated with Prof. Padmanabhan Balaram, a noted biochemist and Padma Bhushan award recipient. In 1991, he was awarded the PhD for his thesis “Conformational studies on globular proteins: Data analysis”. To note, CR, as he is fondly called, had worked on the Ramachandran plot project together with GNR. Thus, Srinivasan has been brought up in this famous legacy of genuinely Indian-born science. He was always highly passionate and excited about his recent works on revisiting the Ramachandran map as well as about the collaboration with CR, his PhD guru. Whereas the backbone dihedral angle calculations were done manually in the early work, it was redone using computers also accounting for possible deviations from ideal bond length and bond angle parameters of the peptide unit. Such a reexamination provided a stereochemical rationale, as conceptualized by Srinivasan, for why certain regions of the Ramachandran map areas albeit “disallowed,” using ideal internal parameters, are actually tolerated in protein structures. Srinivasan's joy knew no bounds when this work of four generations—GNR, CR, N. Srinivasan, and his students' and coworkers' publications—was accepted in reputed journals and gained international attention. His postdoctoral period was very intensive. After having been a senior research fellow at IISc (in the group of Prof. Balaram) for 10 months, he moved to Tom Blundell's lab at Birkbeck College London (1991–1994). Together with Mini, Srini spent most of the time, even on weekends, in the lab. Srini used to engage in conversation with Prof. Tom Blundell on new and newer projects. Tom started getting quite worried if the couple may not be having enough relaxing time and he had secret ploys to get them walk along the banks of Thames River and listen to opera music in theaters. For the following 2 years, N. Srinivasan accepted an offer from Mike Waterfield at the Ludwig Institute for Cancer Research in London. From 1996 to 1998, he was reunited with Tom Blundell who had moved to the Department of Biochemistry of Cambridge University. Srinivasan left Received: 18 November 2021 Accepted: 22 November 2021
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