Some Isomers of Nevirapine - A DFT Study

Nevirapine is a dipyridodiazepinone and representative of a new class of anti-HIV agents, the non-nucleoside reverse transcriptase inhibitors. The effect of some centric perturbations on some properties of nevirapine have been investigated within the limitations of density at the level of B3LYP/6-31++G(d,p). The calculations have revealed that the isomers constructed are all thermally favorable and electronically stable. Various calculated properties of the isomers including geometrical, electronic, thermo chemical, quantum chemical and some spectral properties have been harvested and discussed. Additionally, nucleus-independent chemical shift, NICS(0), calculations have been performed and the effect of perturbations on the local aromaticity of six-membered rings have been investigated. The effect of monocentric carbon to nitrogen perturbations on the chemical function descriptors have been determined. Also, the variation of polar surface areas (PSA) of the isomers have been considered in relation to their ability to penetrate the blood-brain barrier.