秀丽隐杆线虫作为衰老研究的模型

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2018-03-01 DOI:10.1016/j.ddmod.2018.11.001

Hildegard I.D. Mack , Thomas Heimbucher , Coleen T. Murphy

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引用次数: 38

摘要

秀丽隐杆线虫(Caenorhabditis elegans)是衰老遗传调控实验研究的关键模型系统，为该领域的许多重要发现铺平了道路。重要的是，秀丽隐杆线虫在其约3周的短暂寿命中表现出许多表型、行为和分子变化，这些变化在后生动物中随着年龄的增长而广泛共享。在本文中，我们总结了衰老研究如何利用秀丽隐杆线虫的生物学，并介绍了可用于研究蠕虫衰老的实验工具箱。

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The nematode Caenorhabditis elegans as a model for aging research

The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.