利用替代反应介质强化生物催化过程

Q2 Physics and Astronomy
André Delavault, K. Ochsenreither, C. Syldatk
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引用次数: 1

摘要

工业上生物催化过程的性能常常受到生产率、产物浓度和生物催化剂稳定性的限制。原因可能是不利的反应热力学,底物的水溶性低或由高底物或产物浓度引起的抑制。克服这些限制和提高工艺经济竞争力的一种方法是使用替代反应介质进行过程强化(PI)。在工业生物转化过程的早期,研究表明,许多有趣的有机合成目标产物在非常规反应介质中比在缓冲水溶液中更容易溶解,有时甚至更稳定。此外,通常也希望无水,以防止副作用和降解反应以及微生物污染,这反过来又消除了在无菌条件下工作的需要,从而减少了能量消耗。此外,人们很早就发现,溶剂对酶的活性和稳定性的影响完全不同,这取决于它们的亲水性,因此,如果它们与后者形成相当单相或双相系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intensification of biocatalytic processes by using alternative reaction media
Abstract Performances of biocatalytic processes in industry are often limited by productivity, product concentration and biocatalyst stability. Reasons can be such as unfavourable reaction thermodynamics, low water solubility of the substrates or inhibition caused by high substrate or product concentrations. A way to overcome these limitations and to enhance economic competitiveness of the process can be process intensification (PI) using an alternative reaction medium. Very early in industrial biotransformation processes, it was shown that many interesting target products of organic synthesis are much more soluble and sometimes even more stable in non-conventional reaction media than in buffered aqueous solutions. Moreover, the absence of water is also generally desired to prevent side and degradation reactions as well as microbial contamination, which in turn eliminates the need to work under sterile conditions thereby reducing energy expenditure. In addition, it was also discovered early on that solvents can influence the activity and stability of enzymes quite differently depending on their water affinity and thus if they form rather monophasic or biphasic systems with the latter.
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来源期刊
Physical Sciences Reviews
Physical Sciences Reviews MULTIDISCIPLINARY SCIENCES-
CiteScore
2.40
自引率
0.00%
发文量
173
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