Formulation and in-vitro evaluation of moxifloxacin loaded crosslinked chitosan films for the treatment of periodontitis

Aim

The purpose of the present work was to develop a local drug delivery system of moxifloxacin loaded crosslinked chitosan films using sodium citrate as a crosslinking agent with different concentrations and crosslinking time.

Methods

The films were prepared using solvent casting technique. The formulated films were evaluated for physicochemical parameters like FT-IR, DSC, thickness, weight variation, content uniformity, surface pH and release kinetics.

Results

IR and DSC studies indicated that there is no interaction between the drug and excipients. The drug loaded chitosan films were flexible, possessed good tensile strength and demonstrated satisfactory physicochemical characteristics. Although the films showed an initial burst release of drug, the release was sustained for up to 15 days. From the obtained results F6 formulation is optimized one among all the formulations.

Conclusion

The present work suggests that the controlled release Moxifloxacin loaded Chitosan films crosslinked with sodium citrate have a remarkable role in the local therapy of periodontitis.