A. Babandi, N. Musa, M. Ya’u, H. Yakasai, D. Shehu, K. Babagana, A. Ibrahim
{"title":"高脂血症大鼠高脂饮食中富黄酮部分的降脂作用","authors":"A. Babandi, N. Musa, M. Ya’u, H. Yakasai, D. Shehu, K. Babagana, A. Ibrahim","doi":"10.17706/IJBBB.2019.9.1.42-50","DOIUrl":null,"url":null,"abstract":"The lipid-lowering potential of flavonoid-rich portion of Combretum micranthum (CM) on a high-fat diet (HFD) induced albino rats was evaluated. Hyperlipidaemic rats were divided into six groups. Group I (Normal control), group II (HFD-fed only), while group III, IV and V received aqueous methanol (80%) leaf extract of CM at varied doses of 100, 200 and 400 mg/kg, respectively, while group VI were given the standard drugAtorvastatin (4 mg/kg) for two weeks. Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoproteins (HDL-C), Creatine Kinase (CK), and Lactate Dehydrogenase (LDH) were assayed spectrophotometrically and Atherogenic Index (AI) calculated using standard formula. GC-MS revealed 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 5-oxycatechol and 1,2,3benzenetriol to be the principal compounds. Significant reduction in TC, TAG, LDL-C, AI, CK, LDH and increased in HDL-C were observed compared to hyperlipidemic control (p<0.05) hence CM could be used in the management of risk of CVDs.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"42 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Lipid-Lowering Property of Flavonoid-Rich Portion of Combretum Micranthumon High Fat Diet Induced Hyperlipidemic Rats\",\"authors\":\"A. Babandi, N. Musa, M. Ya’u, H. Yakasai, D. Shehu, K. Babagana, A. Ibrahim\",\"doi\":\"10.17706/IJBBB.2019.9.1.42-50\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The lipid-lowering potential of flavonoid-rich portion of Combretum micranthum (CM) on a high-fat diet (HFD) induced albino rats was evaluated. Hyperlipidaemic rats were divided into six groups. Group I (Normal control), group II (HFD-fed only), while group III, IV and V received aqueous methanol (80%) leaf extract of CM at varied doses of 100, 200 and 400 mg/kg, respectively, while group VI were given the standard drugAtorvastatin (4 mg/kg) for two weeks. Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoproteins (HDL-C), Creatine Kinase (CK), and Lactate Dehydrogenase (LDH) were assayed spectrophotometrically and Atherogenic Index (AI) calculated using standard formula. GC-MS revealed 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 5-oxycatechol and 1,2,3benzenetriol to be the principal compounds. Significant reduction in TC, TAG, LDL-C, AI, CK, LDH and increased in HDL-C were observed compared to hyperlipidemic control (p<0.05) hence CM could be used in the management of risk of CVDs.\",\"PeriodicalId\":13816,\"journal\":{\"name\":\"International Journal of Bioscience, Biochemistry and Bioinformatics\",\"volume\":\"42 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Bioscience, Biochemistry and Bioinformatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17706/IJBBB.2019.9.1.42-50\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Bioscience, Biochemistry and Bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17706/IJBBB.2019.9.1.42-50","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lipid-Lowering Property of Flavonoid-Rich Portion of Combretum Micranthumon High Fat Diet Induced Hyperlipidemic Rats
The lipid-lowering potential of flavonoid-rich portion of Combretum micranthum (CM) on a high-fat diet (HFD) induced albino rats was evaluated. Hyperlipidaemic rats were divided into six groups. Group I (Normal control), group II (HFD-fed only), while group III, IV and V received aqueous methanol (80%) leaf extract of CM at varied doses of 100, 200 and 400 mg/kg, respectively, while group VI were given the standard drugAtorvastatin (4 mg/kg) for two weeks. Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoproteins (HDL-C), Creatine Kinase (CK), and Lactate Dehydrogenase (LDH) were assayed spectrophotometrically and Atherogenic Index (AI) calculated using standard formula. GC-MS revealed 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 5-oxycatechol and 1,2,3benzenetriol to be the principal compounds. Significant reduction in TC, TAG, LDL-C, AI, CK, LDH and increased in HDL-C were observed compared to hyperlipidemic control (p<0.05) hence CM could be used in the management of risk of CVDs.
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