{"title":"HPLC-UV法测定黄芪地上部位中儿茶素和没食子酸的含量。","authors":"L. Roman, Kozachok Solomiia","doi":"10.3329/dujps.v18i2.44464","DOIUrl":null,"url":null,"abstract":"The aerial part of Astragalus glycyphyllos L. (Astragali glycyphylli herba), a promising nephroprotective agent in folk medicine, has been investigated by HPLC-UV for occurrence of catechins, which are known in individual state as renoprotective substances and gallic acid. The following six compounds were detected and quantitatively determined in the analyzed plant material: (-)-gallocatechin, (-)-epigallocatechin, (+)-catechin, (-)-epicatechin, (-)-epicatechin gallate and gallic acid. The highest yield amongst the flavan-3-ols was found for (-)-gallocatechin (3.7 mg/g) and (-)-epigallocatechin (1.7 mg/g). The determined content of gallic acid was 0.4 mg/g. The investigated material should be subjected for further studies to substantiate the recommendation for its wider employment in current phytotherapeutic practice.","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":"4 1","pages":"241-247"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"HPLC-UV Determination of Catechins and Gallic Acid in Aerial Parts of Astragalus glycyphyllos L.\",\"authors\":\"L. Roman, Kozachok Solomiia\",\"doi\":\"10.3329/dujps.v18i2.44464\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aerial part of Astragalus glycyphyllos L. (Astragali glycyphylli herba), a promising nephroprotective agent in folk medicine, has been investigated by HPLC-UV for occurrence of catechins, which are known in individual state as renoprotective substances and gallic acid. The following six compounds were detected and quantitatively determined in the analyzed plant material: (-)-gallocatechin, (-)-epigallocatechin, (+)-catechin, (-)-epicatechin, (-)-epicatechin gallate and gallic acid. The highest yield amongst the flavan-3-ols was found for (-)-gallocatechin (3.7 mg/g) and (-)-epigallocatechin (1.7 mg/g). The determined content of gallic acid was 0.4 mg/g. The investigated material should be subjected for further studies to substantiate the recommendation for its wider employment in current phytotherapeutic practice.\",\"PeriodicalId\":11304,\"journal\":{\"name\":\"Dhaka University Journal of Pharmaceutical Sciences\",\"volume\":\"4 1\",\"pages\":\"241-247\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dhaka University Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/dujps.v18i2.44464\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dhaka University Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/dujps.v18i2.44464","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HPLC-UV Determination of Catechins and Gallic Acid in Aerial Parts of Astragalus glycyphyllos L.
The aerial part of Astragalus glycyphyllos L. (Astragali glycyphylli herba), a promising nephroprotective agent in folk medicine, has been investigated by HPLC-UV for occurrence of catechins, which are known in individual state as renoprotective substances and gallic acid. The following six compounds were detected and quantitatively determined in the analyzed plant material: (-)-gallocatechin, (-)-epigallocatechin, (+)-catechin, (-)-epicatechin, (-)-epicatechin gallate and gallic acid. The highest yield amongst the flavan-3-ols was found for (-)-gallocatechin (3.7 mg/g) and (-)-epigallocatechin (1.7 mg/g). The determined content of gallic acid was 0.4 mg/g. The investigated material should be subjected for further studies to substantiate the recommendation for its wider employment in current phytotherapeutic practice.
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