疾病动物模型全基因组测序

Yixue Li
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摘要

疾病动物模型的全基因组测序与群体遗传学方法是一种破译与疾病表型相关的新变异的有力技术。这里我们展示了我们对骆驼、狗和兔子的研究。从这些动物身上获得全基因组测序数据,然后使用群体遗传学方法处理这些全基因组测序数据。发现了一些重要的遗传变异,这些变异与疾病相关的表型密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Whole genome sequencing of disease animal models
Whole genome sequencing of disease animal models together with population genetics methodology is a powerful technology for deciphering new variations which associated with disease phenotypes. Here we show our studies on camel, dog, and rabbit. Whole genome sequencing data were generated from those animals, and then population genetics methodology was used in dealing with these whole genome sequencing date. Some important genetic variations were discovered which shown a strong association with disease related phenotypes.
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