婴儿血管瘤自发复发的可能机制

Bioscience hypotheses Pub Date : 2009-01-01 DOI:10.1016/j.bihy.2009.01.006

X.J. Yang , J.W. Zheng , Q. Zhou , W.M. Ye , Y.A. Wang , H.G. Zhu , Z.Y. Zhang , L.Z. Wang

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引用次数: 1

摘要

婴儿血管瘤是一种常见的血管肿瘤，其表现为快速增殖期，随后长时间自发结缔组织。形成和发展机制尚不清楚。最近的研究表明，血管瘤来源的干细胞具有多向分化的能力，包括内皮细胞和间充质细胞的分化。此外，间充质干细胞还具有诱导内皮细胞凋亡、分化为脂肪细胞和引发血管瘤内陷的能力。因此，我们推测间充质干细胞可能是血管瘤自发消退的来源。间充质干细胞治疗血管瘤的潜在疗效有待进一步研究。

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A possible mechanism of spontaneous involution of infantile hemangioma

Infantile hemangiomas are common vascular tumours which exhibit a rapid proliferating phase followed by spontaneously involuting for a long time. The formation and development mechanisms are not clear yet. Recent studies show that hemangioma-derived stem cells have multipotential differentiation abilities, including endothelial and mesenchymal differentiation. In addition, mesenchymal stem cell has the capability of inducing endothelial cell apoptosis, differentiating into adipocytes and triggering the involution of hemangiomas. Thus we hypothesize that mesenchymal stem cell may be the source of spontaneously regression of hemangiomas. Further investigations may be needed to develop potential therapeutic implications of mesenchymal stem cell in treating hemangiomas.

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Bioscience hypotheses

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