子痫前期孕妇血液微量元素水平:综合系统评价和荟萃分析

IF 0.2 Q4 PHARMACOLOGY & PHARMACY
Wening Hapsari, Achmad Januar Er Putra
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引用次数: 0

摘要

微量元素缺乏在孕妇中是常见的,可能导致先兆子痫的发展。本荟萃分析旨在测定子痫前期妇女与健康孕妇相比的钙、镁、锌、铁和铜的血清水平。方法:从启动到2022年3月25日,在PubMed、ScienceDirect和Google Scholar中以“钙”或“镁”或“锌”或“铜”或“铁”或“微量元素”或“微量元素”、“血清”或“血液”、“子痫前期”等关键词进行系统检索。来自PubMed、ScienceDirect和Google Scholar的文章分别为62篇、31篇和119篇。文章筛选过程基于PRISMA 2020指南。研究质量采用nos进行评估。结果:本系统综述纳入54项研究。合并分析显示血清钙(SMD = (-1.66;95% CI = -2.05 ~ -1.28,镁(SMD = -1.28;95% CI = -1.37 ~ -1.20,锌在子痫前期显著降低(SMD = -2.4;95% CI = -4.11 ~ -0.7。子痫前期血清铁含量较高(SMD = 1.71;95% CI = 0.21 ~ 3.21)。血清铜水平差异无统计学意义。结论:与健康孕妇组相比,子痫前期妇女的平均血钙、镁和锌水平明显较低,而血铁水平较高。两组之间的铜含量没有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Maternal Blood Trace Element Levels in Preeclampsia: Comprehensive Systematic Review and Meta-Analysis
Introduction: Deficit in trace elements was frequent in pregnant women and could lead to preeclampsia development. This meta-analysis aimed to determine calcium, magnesium, zinc, iron, and copper serum levels in preeclampsia women compared to healthy pregnant women. Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar from inception into March 25th, 2022 using keywords of “("calcium" OR "magnesium" OR "zinc" OR "copper" OR "iron" OR "trace element" OR "trace elements") AND ("serum" OR "blood") AND ("preeclampsia")”. Articles obtained from PubMed, ScienceDirect, and Google Scholar were 62, 31, and 119 respectively.  The article screening process was based on the PRISMA 2020 guidelines. Study quality was assessed using NOS. Results: Fifty-four studies were included in this systematic review. Pooled analysis revealed that serum calcium (SMD = (-1.66; 95% CI = -2.05 to -1.28, magnesium (SMD = -1.28; 95% CI = -1.37 to -1.20, and zinc were significantly lower in preeclampsia (SMD = -2.4; 95% CI = -4.11 to -0.7. Serum iron was higher in preeclampsia (SMD = 1.71; 95% CI = 0.21 to 3.21). No significant different difference in serum copper level. Conclusion: The mean blood levels of calcium, magnesium, and zinc were considerably lower, while blood iron levels were higher in preeclamptic women compared to the healthy pregnant group. Copper levels were not significantly different between the two groups.
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