Dronedarone:房颤治疗的新选择

Future Prescriber Pub Date : 2009-02-26 DOI:10.1002/fps.45

Professor A. John Camm MD, Irina Savelieva MD

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引用次数: 0

摘要

目前正在研究许多利用新的作用机制的抗心律失常药物(以及传统抗心律失常药物的改良类似物，具有离子通道和受体阻断作用的不同组合以及不太复杂的代谢谱)。克隆酮是一种胺碘酮衍生物，不含碘原子，被认为比胺碘酮具有更好的安全性。它是治疗心房颤动(AF)的唯一抗心律失常药物，已被证明可提高高危患者的生存率。本综述提供了关于drone - edarone临床发展的当代见解，它在预防复发性房颤中的有效性和安全性，以及它在改善房颤患者预后方面的潜在额外优势。版权©2009 John Wiley &儿子,有限公司

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dronedarone: a new option in atrial fibrillation

Many antiarrhythmic agents exploiting new mechanisms of action (as well as modified analogues of traditional antiarrhythmic drugs, with different combinations of ion channel- and receptor-blocking effects and less complicated metabolic profiles) are currently being investigated. Dronedarone is an amiodarone derivative that is devoid of iodine atoms and is believed to have a better safety profile than amiodarone. It is the only antiarrhythmic drug for the treatment of atrial fibrillation (AF) that has been shown to improve survival in high-risk patients. This review provides a contemporary insight into the clinical development of dronedarone, its efficacy and safety in preventing recurrent AF, and its potential additional advantage of improving outcome in patients with AF. Copyright © 2009 John Wiley & Sons, Ltd.

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Future Prescriber

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