人类白细胞抗原等位基因共享在异性伴侣间人乳头瘤病毒感染传播中的作用:来自HITCH队列研究的发现

K. Louvanto, Prativa Baral, A. Burchell, A. Ramanakumar, M. El-Zein, P. Tellier, F. Coutlée, M. Roger, E. Franco
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引用次数: 0

摘要

人类白细胞抗原(HLA)多态性影响先天和适应性免疫反应。在异性恋夫妇中通过异性恋活动进行HPV感染和传播(HITCH)队列研究中,我们研究了一对夫妇的等位基因共享是否可以预测伴侣感染相同类型的人乳头瘤病毒(HPV)。方法采用聚合酶链反应对271对夫妇生殖器标本进行36种HPV基因型检测。我们使用直接DNA测序对HLA-B07, -DRB1, -DQB1和-G型进行检测。使用广义估计方程来检查等位基因共享程度与HPV型一致性之间的关系,其中至少有一个伴侣是HPV阳性。结果共鉴定出106个不同的HLA等位基因。夫妻中最常见的HLA等位基因为G*01:01:01(95.6%)、G*01:01:02(60.1%)、DQB1*03:01(57.2%)和DRB1*07:01(46.9%)。等位基因共享率为:无共享19.6%,仅共享1等位基因43.2%,共享2等位基因25.1%,共享3-5等位基因12.5%。无论HLA类型、分组或组合,等位基因共享程度都不是一对夫妇类型特异性HPV一致性的显著预测因子(优势比为1.1[95%置信区间,0.5 - 2.1],3-5 vs无)。结论:我们没有发现HLA等位基因的一致性程度影响新形成的异性伴侣中HPV传播的可能性的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Human Leukocyte Antigen Allele Sharing in Human Papillomavirus Infection Transmission Among Heterosexual Couples: Findings From the HITCH Cohort Study
Abstract Background Human leukocyte antigen (HLA) polymorphism influences innate and adaptive immune responses. Among heterosexual couples in the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) cohort study, we examined whether allele sharing in a couple predicted the partners’ infections with the same human papillomavirus (HPV) type. Methods We tested genital samples from 271 couples for 36 HPV genotypes by polymerase chain reaction. We used direct DNA sequencing to type HLA-B07, -DRB1, -DQB1 and -G. Generalized estimating equations were used to examine the associations between the extent of allele sharing and HPV type concordance in which at least 1 of the partners was HPV positive. Results We identified 106 different HLA alleles. The most common HLA alleles among couples were G*01:01:01 (95.6%), G*01:01:02 (60.1%), DQB1*03:01 (57.2%), and DRB1*07:01 (46.9%). Allele sharing was as follows: 19.6% shared none, 43.2% shared 1 only, 25.1% shared 2, and 12.5% shared 3–5. Irrespective of HLA class, grouped or in combination, the extent of allele sharing was not a significant predictor of type-specific HPV concordance in a couple (odds ratio, 1.1 [95% confidence interval, .5–2.1], for 3–5 vs none). Conclusions We found no evidence that the extent of HLA allele concordance influences the likelihood of HPV transmission in newly formed heterosexual couples.
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