The Effect of Bacillus subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity

Objective: Bacillus subtilis probiotics have been shown to influence several aspects of the human gut including motility, epithelial strength, inflammation, etc. that may change bowel movement frequency and/or type. To explore the efficacy of Bacillus subtilis (B. subtilis) DE111 in this regard, 50 people were evaluated by their stool profile, food diary and questionnaire while taking a probiotic or placebo daily over the course of 105-days.Method: The stools were scored based on the Bristol Stool Chart index and safety was assessed using blood markers during the 0, 45 and 105 days.Results: Statistically significant results showed those in the DE111 group moved to a healthier bowel index while those in the Placebo group stayed the same.Conclusion: The study provided evidence that DE111 may improve occasional constipation and/or diarrhea in healthy individuals.