ANALGESIC ACTIVITY OF CRUDE HYDRO-ALCOHOLIC EXTRACT OF SALVADORA PERSICA ROOT

Salvadora persica has been widely used for its reported biological activity in indigenous system of medicines. The main objective of the present investigation is to evaluate the analgesic activity of hydroalcoholic extract of Salvadora persica root on mice. Analgesic activity of hydro-alcoholic extract of Salvadora persica root at a dose of 100 mg/Kg, 200 mg /Kg and 400 mg /Kg were evaluated against drug pentazocine at a dose of 17.5 mg/Kg. Adult albino mice and rats of either sex of six numbers in each group were under taken for study and evaluated by eddy’s hot plate and tail immersion method. The all doses of Salvadora persica root crude hydro-alcoholic extract were found to produce significant (P<0.05) analgesic activity. In eddy’s hot plate and tail immersion, both method showed significant activity (P<0.05) after 30 minutes. The result showed significant analgesic activity against stimuli.