心肌梗死急性期全身性与局部炎症的生物标志物,作为梗死后心力衰竭的预测因子

IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
B. Mátyás, Ș. Polexa, I. Benedek, Andreea-Luciana Buicu, T. Benedek
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引用次数: 2

摘要

背景:本研究旨在探讨急性发作后第1天左心室功能障碍血清生物标志物与全身性炎症的相关性,并探讨其在梗死后心力衰竭高危患者早期识别中的作用。材料与方法:本研究回顾性分析了罗马尼亚t rgu穆雷涅斯县临床急救医院心脏病学门诊心血管重症监护室收治的123例急性心肌梗死患者。根据NT-proBNP水平将研究人群分为2组:1组(n = 92), NT-proBNP为3000 pg/mL。结果:反映全身性炎症的生物标志物在NT-proBNP升高的患者中表现出更高的值(hs-CRP - 12.3±8.9 mg/L vs. 3.6±6.7 mg/L, p <0.0001,白细胞介素6 - 27.6±30.7 pg/mL vs. 8.6±6.2 pg/mL, p <0.0001)。细胞粘附分子VCAM和ICAM在各组间无显著差异。2组患者急性冠状动脉事件发生后1年内的主要心血管事件发生率和再住院率均显著高于1组,分别为13.33%和8.7% (p <0.05)。结论:急性心肌梗死后即刻期,心室功能障碍的血清生物标志物与全身性炎症和心室损伤密切相关。与细胞粘附分子表达的局部冠状动脉炎症相比,全身性炎症对临床结果和心力衰竭进展的影响更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers of Systemic Versus Local Inflammation During the Acute Phase of Myocardial Infarction, as Predictors of Post-infarction Heart Failure
Abstract Background: The aim of this study was to investigate the correlation between serum biomarkers of left ventricular dysfunction and systemic inflammation in the first days after the acute episode, and to investigate their role for early identification of patients at high risk for post-infarction heart failure. Materials and methods: In total, 123 subjects admitted to the Intensive Cardiovascular Care Unit of the Cardiology Clinic of the Târgu Mureș County Clinical Emergency Hospital, Romania, with acute myocardial infarction were retrospectively analyzed in this study. Based on the level of NT-proBNP, the study population was divided into 2 groups: Group 1 (n = 92), with NT-proBNP <3,000 pg/mL, and Group 2 (n = 31), with NT-proBNP >3,000 pg/mL. Results: Biomarkers reflecting systemic inflammation presented significantly higher values in patients with elevated NT-proBNP (hs-CRP – 12.3 ± 8.9 mg/L vs. 3.6 ± 6.7 mg/L, p <0.0001, and interleukin 6 – 27.6 ± 30.7 pg/mL vs. 8.6 ± 6.2 pg/mL, p <0.0001). However, cell adhesion molecules VCAM and ICAM were not significantly different between the groups. Patients in Group 2 presented significantly higher rates of major cardiovascular events and rehospitalizations in the first year after the acute coronary event, with 13.33% event rate for patients in Group 2 compared to 8.7% in Group 1 (p <0.05). Conclusions: Serum biomarkers of ventricular dysfunction are strongly associated with systemic inflammation and ventricular impairment in the immediate phase after an acute myocardial infarction. Systemic inflammation has a higher impact on the clinical outcomes and progression to heart failure than the local coronary inflammation expressed by cell adhesion molecules.
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