干扰素治疗多发性硬化症的进展

O. Boyko, N. Smirnova, A. N. Boyko
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引用次数: 0

摘要

本文回顾了干扰素-β (IFN-β)在多发性硬化症(MS)治疗中的演变,从最初的高剂量干扰素到最近的聚乙二醇化形式。提出并讨论了关键试验的结果。第一次IFN-β治疗的主要问题是:1)在存在中和抗体(NAB, 20%的治疗患者)的情况下,疗效一般,导致疗效下降;2)由于频繁注射(每隔一天注射一次),耐受性差;3)严重的局部反应和流感样综合征。Pegillation可以延长给药时间至每14天注射一次,并将NAB的概率降低到所有治疗患者的1%以下。第一种皮下注射的药物有明显的流感样综合征;国产药物SamPEG-IFN-β1a肌注耐受性较好,疗效相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The evolution of interferon therapy in multiple sclerosis
The article reviews the evolution of interferon-β (IFN-β) in the treatment of multiple sclerosis (MS) from the first high-dose interferons to the most recent pegylated forms. The results of pivotal trials are presented and discussed. The main problems of the first IFN-β were: 1) moderate efficacy in the presence of neutralizing antibodies (NAB, in 20% of treated patients), leading to a decrease in efficacy, 2) poor tolerability due to frequent injections (every other day), 3) severe local reactions and flu-like syndrome. Pegillation made it possible to extend the duration of administration to one injection every 14 days and to reduce the probability of NAB to less than 1% of all treated patients. The first drug administered subcutaneously had a pronounced flu-like syndrome; the domestic drug SamPEG-IFN-β1a administered intramuscularly was better tolerated with similar efficacy.
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