一种新型抗菌表面消毒剂在干、湿状态下的比较效果和抗菌持久性

Bahgat Z Gerges, J. Rosenblatt, Ying Jiang, I. Raad
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引用次数: 0

摘要

目的:我们评估了一种新型消毒剂(VR)和7种比较剂(消毒剂a - g)对卫生保健环境中常见的耐药病原体的作用。方法与结果:采用不同稀释度的VR,以及商业消毒剂A-G,对替代病毒、耐药细菌和真菌病原体进行了检测。替代病毒的初始浓度为~1 × 108 mL−1,细菌和真菌分离物在硅表面的初始浓度为~1 × 106 mL−1。应用VR或比较消毒剂后,在30秒和5分钟的湿暴露以及24小时的干残留物暴露后,测试表面微生物负荷的减少情况。无菌去离子水作为对照。在湿法和干法试验中,浓度为4.68%的杀菌剂对大多数病原菌的杀菌力均优于所有比较消毒剂。在所有比较剂消毒剂中,浓度为7.8%的杀菌剂对所有病原体的杀菌率最高。结论:总体而言,新型VR消毒剂在湿残留和干残留状态下对检测的病原体都是最有效的消毒剂。研究的意义和影响:VR是一种广泛有效的消毒剂组合,适用于高风险环境,特别是那些消毒剂应用间隔可能很长或不一致的环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant
Aims: We evaluated a novel disinfectant (VR) and seven comparators (disinfectants A–G) against resistant pathogens common in healthcare settings. Methods and Results: VR at different dilutions, along with commercial disinfectants A–G, was tested against surrogate viruses, and resistant bacterial and fungal pathogens. Surrogate viruses had an initial concentration of ~1 × 108 mL−1, and bacterial and fungal isolates had an initial concentration of ~1 × 106 mL−1 on Siliconee surfaces. After the application of VR or a comparator disinfectant, surfaces were tested for the reduction in microbial loads after 30 s and 5 min wet exposures, and after a 24 h dry residue exposure. Sterile deionized water was used as a control. The VR at a concentration of 4.68% was superior to all comparator disinfectants against most pathogens in wet and dry testing. The VR at 7.8% concentration showed the highest pathogen-reduction rate among all comparator disinfectants when tested against all pathogens. Conclusions: Overall, the novel VR disinfectant was the most effective disinfectant in both wet and dry residue states against the range of tested pathogens. Significance and Impact of the Study: VR is a broadly effective disinfectant combination for use in high-risk settings, particularly those in which intervals between applications of disinfectant can be lengthy or inconsistent.
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