动物模型的呼吸力学分析:它在理解肺气肿和哮喘的肺行为中的应用

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2019-06-01 DOI:10.1016/j.ddmod.2019.10.001

Paolo José Cesare Biselli , Julia Benini Kohler , Renato Righetti , Iolanda de Fátima Lopes Calvo Tibério , Mílton de Arruda Martins , Fernanda Degobbi Tenorio Quirino dos Santos Lopes

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引用次数: 2

摘要

呼吸系统疾病动物模型的呼吸力学评估被认为是了解结构变化如何影响肺功能的可靠工具。数学模型，如运动方程和恒相模型被用来描述呼吸系统的特性。运动方程之所以受到重视，是因为它应用起来相对简单，而且用很少的参数来描述呼吸系统。恒相模型更为复杂，但提供了更多关于不同肺室的详细信息。在这篇综述中，我们总结了如何使用呼吸力学来描述肺行为，以及这些测量如何反映肺气肿和哮喘引起的动物模型结构变化的进展。

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Analysis of respiratory mechanics in animal models: Its use in understanding lung behavior in emphysema and asthma

Respiratory mechanics assessment in animal models of respiratory diseases is considered a reliable tool to understand how structural changes impact lung function. Mathematical models, such as the equation of motion and the constant-phase model are used to describe the properties of the respiratory system. The equation of motion is valued because it is relatively simple to apply and describes the respiratory systems with few parameters. The constant-phase model is more complex but provides more detailed information about different lung compartments. In this review, we summarize how respiratory mechanics have been used to describe lung behavior as well as how these measurements reflect the progression of structural changes caused by emphysema and asthma in animal models.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.